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Carbohydr. Polym., 2 January 2024 | https://doi.org/10.1016/j.carbpol.2023.121734 Enhancing cartilage regeneration through spheroid culture and hyaluronic acid microparticles: A promising approach for tissue engineering

Hye-Eun Shim^a,b,1, Yong-Jin Kim ^c,1, Kyoung Hwan Park ^a,b, Honghyun Park ^d,2, Kang Moo Huh ^b,2, Sun-Woong Kang^a,e,2

^aResearch Group for Biomimetic Advanced Technology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea

^bDepartment of Polymer Science and Engineering, Chungnam National University, Daejeon 34134, Republic of Korea

^cAP APAC R&I, Singapore 138667, Singapore

^dDepartment of Advanced Biomaterials Research, Ceramics Materials Division, Korea Institute of Materials Science, Changwon 51508, Republic of Korea

^eDepartment of Human and Environmental Toxicology, University of Science and Technology, Daejeon 34114, Republic of Korea

¹These authors contributed equally to this work as co-first authors.

²These authors contributed equally to this work as co-corresponding authors.

Corresponding authors : Honghyun Park, Kang Moo Huh, Sun-Woong Kang

Abstract

Cell therapy using chondrocytes has shown promise for cartilage regeneration, but maintaining functional characteristics during in vitro culture and ensuring survival after transplantation are challenges. Three-dimensional (3D) cell culture methods, such as spheroid culture, and hydrogels can improve cell survival and functionality. In this study, a new method of culturing spheroids using hyaluronic acid (HA) microparticles was developed. The spheroids mixed with HA microparticles effectively maintained the functional characteristics of chondrocytes during in vitro culture, resulting in improved cell survival and successful cartilage formation in vivo following transplantation. This new method has the potential to improve cell therapy production for cartilage regeneration.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-16)
연구진국내(교신)+국외 연구진
분야 의약학 > 재생의학

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