안승현 (동아대학교병원) | 한빛사논문 > 한빛사

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안승현Seoung Hyun An

동아대학교병원

Biomaterials, Jan 01 2024, 305 S0142-9612(23)00467-2 | https://doi.org/10.1016/j.biomaterials.2023.122459 Injectable alginate-based in situ self-healable transparent hydrogel as a vitreous substitute with a tamponading function

Geunho Choi ^a,1, Seoung Hyun An ^b,1, Jae-Won Choi ^c, Mee Sook Rho ^d, Woo Chan Park ^b, Woo jin Jeong ^b, Hyung Joon Cha^a,e

^aDepartment of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea

^bDepartment of Ophthalmology, Dong-A University Hospital, Busan 49315, Republic of Korea

^cDepartment of Ophthalmology, Sungmo Eye Hospital, Busan 48064, Republic of Korea

^dDepartment of Pathology, Dong-A University Hospital, Busan 49315, Republic of Korea

^eMedical Science and Engineering, School of Convergence Science and Technology, Pohang University of Science and Technology, Pohang 37673, Republic of Korea

¹These two authors contributed equally to this work.

Corresponding authors: Woo jin Jeong, Hyung Joon Cha

Abstract

Retinal detachment and other vision-threatening disorders often necessitate vitreous body removal and tamponade injection for retina stabilization. Current clinical tamponades such as silicone oil and expansile gases have drawbacks, including patient discomfort and the need for secondary surgery. We introduce a transparent alginate-phenylboronic acid/polyvinyl alcohol composite hydrogel (TALPPH) as a novel vitreous substitute with tamponading capabilities. In vitro physicochemical, rheological, and optical characterization of in situ self-healable TALPPH was performed, and long-term biocompatibility was assessed in a rabbit model of vitrectomy retinal detachment. In vivo evaluations confirmed TALPPH's ability to inhibit retinal detachment recurrence and preserve rabbit vision without adverse effects. TALPPH's close resemblance to the natural vitreous body suggests potential as a vitreous tamponade substitute for future ophthalmological applications.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-11)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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