한빛사
>
한빛사논문
한빛사논문
- 조회266
Angew. Chem.-Int. Edit., Jan 10 2024, | https://doi.org/10.1002/anie.202316487
An ER-targeted, Viscosity-sensitive Hemicyanine Dye for the Diagnosis of Nonalcoholic Fatty Liver and Photodynamic Cancer Therapy by Activating Pyroptosis Pathway
Shuang Zeng 1, Yang Wang 1, Chen Chen 1, Heejeong Kim 2, Xiaosheng Liu 3, Maojun Jiang 1, Yichu Yu 3, Yves S Kafuti 3, Qixian Chen 3, Jingyun Wang 1, Xiaojun Peng 1, Haidong Li 1, Juyoung Yoon 4
1Dalian University of Technology, State Key Laboratory of Fine Chemicals, CHINA.
2Ewha Womans University, Department of Chemistry and Nanoscience, KOREA, REPUBLIC OF.
3Dalian University of Technology, School of Bioengineering, CHINA.
4Ewha Womans University, Department of Chemistry, 11-1 Daehyun-Dong, Seodaemun-Gu, 120-750, Seoul, KOREA, REPUBLIC OF.
CORRESPONDING AUTHOR : Juyoung Yoon
Abstract
The concept of molecular design, integrating diagnostic and therapeutic functions, aligns with the general trend of modern medical advancement. Herein, we rationally designed the smart molecule ER-ZS for endoplasmic reticulum (ER)-targeted diagnosis and treatment in cell and animal models by combining hemicyanine dyes with ER-targeted functional groups (p-toluenesulfonamide). Owing to its ability to target the ER with a highly specific response to viscosity, ER-ZS demonstrated substantial fluorescence turn-on only after binding to the ER, independent of other physiological environments. In addition, ER-ZS, being a small molecule, allows for the diagnosis of nonalcoholic fatty liver disease (NAFLD) via liver imaging based on high ER stress. Importantly, ER-ZS is a type I photosensitizer, producing O2•- and •OH under light irradiation. Thus, after irradiating for a certain period, the photodynamic therapy inflicted severe oxidative damage to the ER of tumor cells in hypoxic (2% O2) conditions and activated the unique pyroptosis pathway, demonstrating excellent antitumor capacity in xenograft tumor models. Hence, the proposed strategy will likely shed new light on integrating molecular optics for NAFLD diagnosis and cancer therapy.
논문정보
- Research article
- 2024년 01월 (BRIC 등록일 2024-01-23)
- 국내(교신)+국외 연구진
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
