박근선 (연세대학교, University of Michigan) | 한빛사논문 > 한빛사

한빛사논문

조회543

연세대학교, University of Michigan

ACS Nano, Jan 08 2024, | https://doi.org/10.1021/acsnano.3c09672 Self-Assembled Nanostructures Presenting Repetitive Arrays of Subunit Antigens for Enhanced Immune Response

Geunseon Park^1,2[+], Woonsung Na3^[+], Jong-Woo Lim⁴, Chaewon Park¹, Sojeong Lee¹, Minjoo Yeom4, Eulhae Ga³, Jaehyun Hwang³, Suyun Moon³, Dae Gwin Jeong^5,6, Hyoung Hwa Jeong⁷, Daesub Song^4*, and Seungjoo Haam^1*

¹Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 03722, Republic of Korea

²Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States

³College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea

⁴Department of Virology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul,08826, Republic of Korea

⁵Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea

⁶Department of Proteome Structural Biology, KRIBB School of Bioscience, University of Science and Technology, Daejeon 34141, Republic of Korea

⁷Huvet Bio Inc., 127 Beobwon-ro, Seoul 05836, Republic of Korea

^*Correspondence to: Daesub Song, Seungjoo Haam

^[+]Geunseon Park and [+]Woonsung Na contributed equally to this work.

Abstract

Infectious diseases pose persistent threats to public health, demanding advanced vaccine technologies. Nanomaterial-based delivery systems offer promising solutions to enhance immunogenicity while minimizing reactogenicity. We introduce a self-assembled vaccine (SAV) platform employing antigen-polymer conjugates designed to facilitate robust immune responses. The SAVs exhibit efficient cellular uptake by dendritic cells (DCs) and macrophages, which are crucial players in the innate immune system. The high-density antigen presentation of this SAV platform enhances the affinity for DCs through multivalent recognition, significantly augmenting humoral immunity. SAV induced high levels of immunoglobulin G (IgG), IgG1, and IgG2a, suggesting that mature DCs efficiently induced B cell activation through multivalent antigen recognition. Universality was confirmed by applying it to respiratory viruses, showcasing its potential as a versatile vaccine platform. Furthermore, we have also demonstrated strong protection against influenza A virus infection with SAV containing hemagglutinin, which is used in influenza A virus subunit vaccines. The efficacy and adaptability of this nanostructured vaccine present potential utility in combating infectious diseases.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-09)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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