한빛사논문
- 조회738
In Bum Lee 1, Eugene Lee 2, Na-Eun Han 1, Marko Slavuj 1, Jeong Wook Hwang 1, Ahrim Lee 1, Taeyoung Sun 1, Yehwan Jeong 1, Ja-Hyun Baik 1, Jae-Yong Park 3, Se-Young Choi 4, Jeehyun Kwag 5 & Bong-June Yoon 1,*
1Department of Life Sciences, Korea University, Seoul 02841, Republic of Korea.
2Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea.
3School of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Republic of Korea.
4Department of Physiology, Dental Research Institute, Seoul National University School of Dentistry, Seoul 03080, Republic of Korea.
5Department of Brain and Cognitive Sciences, Seoul National University, Seoul 08826, Republic of Korea.
*Corresponding author: correspondence to Bong-June Yoon
Abstract
Compulsive behaviors are observed in a range of psychiatric disorders, however the neural substrates underlying the behaviors are not clearly defined. Here we show that the basolateral amygdala-dorsomedial striatum (BLA-DMS) circuit activation leads to the manifestation of compulsive-like behaviors. We revealed that the BLA neurons projecting to the DMS, mainly onto dopamine D1 receptor-expressing neurons, largely overlap with the neuronal population that responds to aversive predator stress, a widely used anxiogenic stressor. Specific optogenetic activation of the BLA-DMS circuit induced a strong anxiety response followed by compulsive grooming. Furthermore, we developed a mouse model for compulsivity displaying a wide spectrum of compulsive-like behaviors by chronically activating the BLA-DMS circuit. In these mice, persistent molecular changes at the BLA-DMS synapses observed were causally related to the compulsive-like phenotypes. Together, our study demonstrates the involvement of the BLA-DMS circuit in the emergence of enduring compulsive-like behaviors via its persistent synaptic changes.
논문정보
- Research article
- 2024년 01월 (BRIC 등록일 2024-01-10)
- 국내 연구진
- 생명과학 > 신경생물학
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