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Exp. Mol. Med., Jan 05 2024, | https://doi.org/10.1038/s12276-023-01151-5 Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration

Jung Hyun Lee^1,2 and Sekyu Choi^3,4,5,6*

¹Department of Dermatology, School of Medicine, University of Washington, Seattle, WA 98109, USA.

²Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.

³Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea.

⁴Medical Science and Engineering, School of Convergence Science and Technology, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea.

⁵School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea.

⁶Institute for Convergence Research and Education in Advanced Technology (I_CREATE), Yonsei University, Incheon 21983, Republic of Korea.

*Corresponding author : Correspondence to Sekyu Choi.

Abstract

Hair follicles, which are connected to sebaceous glands in the skin, undergo cyclic periods of regeneration, degeneration, and rest throughout adult life in mammals. The crucial function of hair follicle stem cells is to maintain these hair growth cycles. Another vital aspect is the activity of melanocyte stem cells, which differentiate into melanin-producing melanocytes, contributing to skin and hair pigmentation. Sebaceous gland stem cells also have a pivotal role in maintaining the skin barrier by regenerating mature sebocytes. These stem cells are maintained in a specialized microenvironment or niche and are regulated by internal and external signals, determining their dynamic behaviors in homeostasis and hair follicle regeneration. The activity of these stem cells is tightly controlled by various factors secreted by the niche components around the hair follicles, as well as immune-mediated damage signals, aging, metabolic status, and stress. In this study, we review these diverse stem cell regulatory and related molecular mechanisms of hair regeneration and disease conditions. Molecular insights would provide new perspectives on the disease mechanisms as well as hair and skin disorder treatment.

논문정보

형식Review Paper
게재일2024년 01월 (BRIC 등록일 2024-01-08)
연구진국내(교신)+국외 연구진
분야 생명과학 > 발생생물학

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