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Nat. Hum. Behav., Jan 05 2024, | https://doi.org/10.1038/s41562-023-01781-9 Shared genetic architectures of educational attainment in East Asian and European populations

Tzu-Ting Chen^1,26, Jaeyoung Kim^2,3,26, Max Lam ^4,5,6,7,8, Yi-Fang Chuang⁹, Yen-Ling Chiu^10,11, Shu-Chin Lin¹, Sang-Hyuk Jung ¹², Beomsu Kim², Soyeon Kim^4,13, Chamlee Cho², Injeong Shim², Sanghyeon Park ², Yeeun Ahn ², Aysu Okbay ¹⁴, Hyemin Jang^15,16, Hee Jin Kim^15,16, Sang Won Seo^15,16, Woong-Yang Park17, Tian Ge13,18,19, Hailiang Huang ^4,5,13, Yen-Chen Anne Feng ^20,21, Yen-Feng Lin ^1,22,23,27, Woojae Myung^3,24,27, Chia-Yen Chen ^25,27 & Hong-Hee Won^2,17,27

¹Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan.

²Department of Digital Health, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea.

³Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.

⁴Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.

⁵Department of Medicine, Harvard Medical School, Boston, MA, USA.

⁶Human Genetics, Genome Institute of Singapore, Singapore, Singapore.

⁷Division of Psychiatry Research, the Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA.

⁸Research Division Institute of Mental Health Singapore, Singapore, Singapore.

⁹Institute of Public Health and International Health Program, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

¹⁰Graduate Institute of Medicine, Yuan Ze University, Taoyuan City, Taiwan.

¹¹Department of Medical Research, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

¹²Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

¹³Stanley Center for Psychiatric Research, the Broad Institute of MIT and Harvard, Cambridge, MA, USA.

¹⁴Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

¹⁵Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

¹⁶Alzheimer’s Disease Convergence Research Center, Samsung Medical Center, Seoul, South Korea.

¹⁷Samsung Genome Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

¹⁸Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

¹⁹Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

²⁰Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei City, Taiwan.

²¹Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, Taiwan.

²²Department of Public Health and Medical Humanities, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

²³Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

²⁴Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.

²⁵Biogen, Cambridge, MA, USA.

²⁶These authors contributed equally: Tzu-Ting Chen, Jaeyoung Kim.

²⁷These authors jointly supervised this work: Yen-Feng Lin, Woojae Myung, Chia-Yen Chen, Hong-Hee Won.

Corresponding authors : Correspondence to Yen-Feng Lin, Woojae Myung, Chia-Yen Chen or Hong-Hee Won.

Abstract

Educational attainment (EduYears), a heritable trait often used as a proxy for cognitive ability, is associated with various health and social outcomes. Previous genome-wide association studies (GWASs) on EduYears have been focused on samples of European (EUR) genetic ancestries. Here we present the first large-scale GWAS of EduYears in people of East Asian (EAS) ancestry (n = 176,400) and conduct a cross-ancestry meta-analysis with EduYears GWAS in people of EUR ancestry (n = 766,345). EduYears showed a high genetic correlation and power-adjusted transferability ratio between EAS and EUR. We also found similar functional enrichment, gene expression enrichment and cross-trait genetic correlations between two populations. Cross-ancestry fine-mapping identified refined credible sets with a higher posterior inclusion probability than single population fine-mapping. Polygenic prediction analysis in four independent EAS and EUR cohorts demonstrated transferability between populations. Our study supports the need for further research on diverse ancestries to increase our understanding of the genetic basis of educational attainment.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-08)
연구진국내(교신)+국외 연구진
분야 생명과학 > 유전학

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