홍진태 (충북대학교) | 한빛사논문 > 한빛사

한빛사논문

조회395

충북대학교

CV File 220 kb

Exp. Mol. Med., Jan 04 2024, | https://doi.org/10.1038/s12276-023-01131-9 Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer

Ji Eun Yu^1,6, In Jun Yeo^1,2,6, Sang-Bae Han¹, Jaesuk Yun¹, Bongcheol Kim³, Yoon Ji Yong⁴, Young-soo Lim⁴, Tae Hun Kim⁵, Dong Ju Son¹ and Jin Tae Hong¹

¹College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31, Osongsaengmyeong 1-ro, Osong-eup, Cheongju-si, Chungbuk 28160, Republic of Korea.

²College of Pharmacy, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Republic of Korea.

³Senelix Co. Ltd., 25, Beobwon-ro 11-gil, Songpa-gu, Seoul 05836, Republic of Korea.

⁴PRESTI GEBIOLOGICS Co. Ltd., Osongsaengmyeong 1-ro, Osong-eup, Cheongju-si, Chungbuk 28161, Republic of Korea.

⁵Autotelic Bio Inc., Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungbuk 28160, Republic of Korea.

⁶These authors contributed equally: Ji Eun Yu, In Jun Yeo.

Corresponding authors : Correspondence to Dong Ju Son or Jin Tae Hong.

Abstract

Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is strongly upregulated by various inflammatory and immunological diseases, including several cancers, Alzheimer's disease, and atherosclerosis. Several studies have shown that CHI3L1 can be considered as a marker of disease diagnosis, prognosis, disease activity, and severity. In addition, the proinflammatory action of CHI3L1 may be mediated via responses to various proinflammatory cytokines, including tumor necrosis factor-α, interleukin-1β, interleukin-6, and interferon-γ. Therefore, CHI3L1 may contribute to a vast array of inflammatory diseases. However, its pathophysiological and pharmacological roles in the development of inflammatory diseases remain unclear. In this article, we review recent findings regarding the roles of CHI3L1 in the development of inflammatory diseases and suggest therapeutic approaches that target CHI3L1.

논문정보

형식Review Paper
게재일2024년 01월 (BRIC 등록일 2024-01-15)
연구진국내 연구진
분야 의약학 > 약학

댓글 작성 로그인

CV 열람하기

연락처 보기