한빛사논문
Kwangwook Kim1,2, Cynthia Jinno1,3, Xunde Li4, David Bravo5,6, Eric Cox7, Peng Ji8 and Yanhong Liu1*
1Department of Animal Science, University of California, Davis, CA 95616, USA
2Present Afliation: Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA
3Present Afliation: Cedars-Sinai Medical Center, Los Angeles, CA 90084, USA
4School of Veterinary Medicine, University of California, Davis, CA 95616, USA
5Pancosma|ADM, 1180 Rolle, Switzerland
6Present Afliation: Nutreco Exploration, Nutreco, The Netherlands
7Department of Virology, Parasitology and Immunology, Ghent University, 9000 Ghent, Belgium
8Department of Nutrition, University of California, Davis, CA 95616, USA
*Correspondence: Yanhong Liu
Abstract
Background: Our previous study has reported that supplementation of oligosaccharide-based polymer enhances gut health and disease resistance of pigs infected with enterotoxigenic E. coli (ETEC) F18 in a manner similar to carbadox. The objective of this study was to investigate the impacts of oligosaccharide-based polymer or antibiotic on the host metabolic profiles and colon microbiota of weaned pigs experimentally infected with ETEC F18.
Results: Multivariate analysis highlighted the differences in the metabolic profiles of serum and colon digesta which were predominantly found between pigs supplemented with oligosaccharide-based polymer and antibiotic. The relative abundance of metabolic markers of immune responses and nutrient metabolisms, such as amino acids and carbohydrates, were significantly differentiated between the oligosaccharide-based polymer and antibiotic groups (q < 0.2 and fold change > 2.0). In addition, pigs in antibiotic had a reduced (P < 0.05) relative abundance of Lachnospiraceae and Lactobacillaceae, whereas had greater (P < 0.05) Clostridiaceae and Streptococcaceae in the colon digesta on d 11 post-inoculation (PI) compared with d 5 PI.
Conclusions: The impact of oligosaccharide-based polymer on the metabolic and microbial profiles of pigs is not fully understood, and further exploration is needed. However, current research suggest that various mechanisms are involved in the enhanced disease resistance and performance in ETEC-challenged pigs by supplementing this polymer.
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