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서울대학교

Carbohydr. Polym., 13 December 2023 | https://doi.org/10.1016/j.carbpol.2023.121634 Progress of polysaccharide-based tissue adhesives

Gi-Yeon Han^a, Ho-Wook Kwack^a, Yo-Han Kim ^b, Yeon Ho Je ^b, Hyun-Joong Kim ^a, Chong-Su Cho ^b

^aProgram in Environmental Materials Science, Department of Agriculture, Forestry and Bioresources, Seoul National University, Seoul 08826, Republic of Korea

^bDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea

Corresponding authors : Hyun-Joong Kim, Chong-Su Cho

Abstract

Recently, polymer-based tissue adhesives (TAs) have gained the attention of scientists and industries as alternatives to sutures for sealing and closing wounds or incisions because of their ease of use, low cost, minimal tissue damage, and short application time. However, poor mechanical properties and weak adhesion strength limit the application of TAs, although numerous studies have attempted to develop new TAs with enhanced performance. Therefore, next-generation TAs with improved multifunctional properties are required. In this review, we address the requirements of polymeric TAs, adhesive characteristics, adhesion strength assessment methods, adhesion mechanisms, applications, advantages and disadvantages, and commercial products of polysaccharide (PS)-based TAs, including chitosan (CS), alginate (AL), dextran (DE), and hyaluronic acid (HA). Additionally, future perspectives are discussed.

논문정보

형식Review Paper
게재일2023년 12월 (BRIC 등록일 2024-01-05)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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