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Nat. Commun., Jan 02 2024, 15 (1) | https://doi.org/10.1038/s41467-023-44064-7 Bionic artificial skin with a fully implantable wireless tactile sensory system for wound healing and restoring skin tactile function

Kyowon Kang ^1,18, Seongryeol Ye ^2,3,18, Chanho Jeong ^4,18, Jinmo Jeong ^5,6,18, Yeong-sinn Ye ⁴, Jin-Young Jeong ⁵, Yu-Jin Kim ², Selin Lim ^1,7, Tae Hee Kim ^2,8, Kyung Yeun Kim ^9,10, Jong Uk Kim ¹¹, Gwan In Kim ^1,12, Do Hoon Chun ¹, Kiho Kim ¹, Jaejin Park ¹, Jung-Hoon Hong ¹, Byeonghak Park ¹³, Kyubeen Kim ¹, Sujin Jung ¹, Kyeongrim Baek¹, Dongjun Cho ¹, Jin Yoo ², Kangwon Lee ^3,14, Huanyu Cheng ¹⁵, Byung-Wook Min ¹, Hyun Jae Kim ¹, Hojeong Jeon ^9,16, Hyunjung Yi ^5,17,* ,Tae-il Kim ^4,*, Ki Jun Yu ^1,7,* & Youngmee Jung ^2,7,*

¹Department of Electrical and Electronic Engineering, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
²Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.
³Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Korea.
⁴School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.
⁵Post-Silicon Semiconductor Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
⁶Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.
⁷School of Electrical and Electronic Engineering, YU-KIST Institute, Yonsei University, Seoul, Republic of Korea.
⁸Department of Fusion Research and Collaboration, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Republic of Korea.
⁹Biomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
¹⁰Department of Mechanical Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
¹¹Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
¹²Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA. ¹³Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
¹⁴Research Institute for Convergence Science, Seoul National University, Seoul 08826, Republic of Korea.
¹⁵Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA. ¹⁶KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea. ¹⁷Department of Materials Science and Engineering, YU-KIST Institute, Yonsei University, Seoul 03722, Republic of Korea. ¹⁸These authors contributed equally: Kyowon Kang, Seongryeol Ye, Chanho Jeong, Jinmo Jeong.

^*Corresponding authors: correspondence to Hyunjung Yi, Tae-il Kim, Ki Jun Yu or Youngmee Jung

Abstract

Tactile function is essential for human life as it enables us to recognize texture and respond to external stimuli, including potential threats with sharp objects that may result in punctures or lacerations. Severe skin damage caused by severe burns, skin cancer, chemical accidents, and industrial accidents damage the structure of the skin tissue as well as the nerve system, resulting in permanent tactile sensory dysfunction, which significantly impacts an individual's daily life. Here, we introduce a fully-implantable wireless powered tactile sensory system embedded artificial skin (WTSA), with stable operation, to restore permanently damaged tactile function and promote wound healing for regenerating severely damaged skin. The fabricated WTSA facilitates (i) replacement of severely damaged tactile sensory with broad biocompatibility, (ii) promoting of skin wound healing and regeneration through collagen and fibrin-based artificial skin (CFAS), and (iii) minimization of foreign body reaction via hydrogel coating on neural interface electrodes. Furthermore, the WTSA shows a stable operation as a sensory system as evidenced by the quantitative analysis of leg movement angle and electromyogram (EMG) signals in response to varying intensities of applied pressures.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-05)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오소재

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