한빛사논문
- 조회670
D. Lugano 1, L. Barrett 1, S. D. Westerheide 1 and Y. Kee 2,*
1Department of Molecular Biosciences, College of Arts and Sciences, University of South Florida, Tampa, FL 33647, USA.
2Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno-Joongang-daero, Dalseong-gun, Daegu 42988, Republic of Korea.
*Corresponding author: correspondence to Y. Kee
Abstract
The cell cycle apoptosis regulator (CCAR) family of proteins consists of two proteins, CCAR1 and CCAR2, that play a variety of roles in cellular physiology and pathology. These multidomain proteins are able to perform multiple interactions and functions, playing roles in processes such as stress responses, metabolism, and the DNA damage response. The evolutionary conservation of CCAR family proteins allows their study in model organisms such as Caenorhabditis elegans, where a role for CCAR in aging was revealed. This review particularly highlights the multifaceted roles of CCAR family proteins and their implications in the DNA damage response and in cancer biology.
논문정보
- Review Paper
- 2024년 01월 (BRIC 등록일 2024-01-04)
- 국내(교신)+국외 연구진
- 생명과학 > 노화/암생물학
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