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조회427

고려대학교

Exp. Mol. Med., 04 January 2024 | https://doi.org/10.1038/s12276-023-01137-3 Relevance of the endoplasmic reticulum-mitochondria axis in cancer diagnosis and therapy

Garam An ^1,3, Junho Park ^1,3, Jisoo Song ², Taeyeon Hong ², Gwonhwa Song ^1,* and Whasun Lim ^2,*

¹Institute of Animal Molecular Biotechnology, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
²Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, Republic of Korea.
³These authors contributed equally: Garam An, Junho Park.

^*Corresponding authors: correspondence to Gwonhwa Song or Whasun Lim

Abstract

Dynamic interactions between organelles are responsible for a variety of intercellular functions, and the endoplasmic reticulum (ER)–mitochondrial axis is recognized as a representative interorganelle system. Several studies have confirmed that most proteins in the physically tethered sites between the ER and mitochondria, called mitochondria-associated ER membranes (MAMs), are vital for intracellular physiology. MAM proteins are involved in the regulation of calcium homeostasis, lipid metabolism, and mitochondrial dynamics and are associated with processes related to intracellular stress conditions, such as oxidative stress and unfolded protein responses. Accumulating evidence has shown that, owing to their extensive involvement in cellular homeostasis, alterations in the ER–mitochondrial axis are one of the etiological factors of tumors. An in-depth understanding of MAM proteins and their impact on cell physiology, particularly in cancers, may help elucidate their potential as diagnostic and therapeutic targets for cancers. For example, the modulation of MAM proteins is utilized not only to target diverse intracellular signaling pathways within cancer cells but also to increase the sensitivity of cancer cells to anticancer reagents and regulate immune cell activities. Therefore, the current review summarizes and discusses recent advances in research on the functional roles of MAM proteins and their characteristics in cancers from a diagnostic perspective. Additionally, this review provides insights into diverse therapeutic strategies that target MAM proteins in various cancer types.

논문정보

형식Review Paper
게재일2024년 01월 (BRIC 등록일 2024-01-04)
연구진국내 연구진
분야 생명과학 > 발생생물학

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