한빛사논문
- 조회253
Inseong Jung 1,4, Sanghee Shin 1,4, Moon-Chang Baek 2,5,* and Kyungmoo Yea 1,3,5,*
1Department of New Biology, DGIST, Daegu 42988, Republic of Korea.
2Department of Molecular Medicine, CMRI, Exosome Convergence Research Center (ECRC), School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
3New Biology Research Center, DGIST, Daegu 43024, Republic of Korea.
4These authors contributed equally: Inseong Jung, Sanghee Shin.
5These authors jointly supervised this work: Moon-Chang Baek, Kyungmoo Yea.
*Corresponding authors: correspondence to Moon-Chang Baek or Kyungmoo Yea
Abstract
Cancer immunotherapy has revolutionized the approach to cancer treatment of malignant tumors by harnessing the body’s immune system to selectively target cancer cells. Despite remarkable advances, there are still challenges in achieving successful clinical responses. Recent evidence suggests that immune cell-derived exosomes modulate the immune system to generate effective antitumor immune responses, making them a cutting-edge therapeutic strategy. However, natural exosomes are limited in clinical application due to their low drug delivery efficiency and insufficient antitumor capacity. Technological advancements have allowed exosome modifications to magnify their intrinsic functions, load different therapeutic cargoes, and preferentially target tumor sites. These engineered exosomes exert potent antitumor effects and have great potential for cancer immunotherapy. In this review, we describe ingenious modification strategies to attain the desired performance. Moreover, we systematically summarize the tumor-controlling properties of engineered immune cell-derived exosomes in innate and adaptive immunity. Collectively, this review provides a comprehensive and intuitive guide for harnessing the potential of modified immune cell-derived exosome-based approaches, offering valuable strategies to enhance and optimize cancer immunotherapy.
논문정보
- Review Paper
- 2024년 01월 (BRIC 등록일 2024-01-05)
- 국내 연구진
- 의약학 > 분자세포의학
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