한빛사논문
- 조회408
Christine Ardelle Marquez1†, Cho‑Im Oh1†, Gna Ahn1,2†, Woo‑Ri Shin1,3, Yang‑Hoon Kim1,2* and Ji‑Young Ahn1,2*
1Department of Microbiology, Chungbuk National University, 1Chungdae‑Ro, Seowon‑Gu, Cheongju 28644, Republic of Korea
2Center for Ecology and Environmental Toxicology, Chungbuk National University, Cheongju 28644, Republic of Korea
3Department of Bioengineering, University of Pennsylvania, 210 S 33rd St, Philadelphia, PA 19104, USA
†Christine Ardelle Marquez, Cho-Im Oh and Gna Ahn contributed equally to this work.
*Correspondence: Yang‑Hoon Kim, Ji‑Young Ahn
Abstract
With the immense progress in drug delivery systems (DDS) and the rise of nanotechnology, challenges such as target specificity remain. The vesicle-vector system (VVS) is a delivery system that uses lipid-based vesicles as vectors for a targeted drug delivery. When modified with target-probing materials, these vesicles become powerful vectors for drug delivery with high target specificity. In this review, we discuss three general types of VVS based on different modification strategies: (1) vesicle-probes; (2) vesicle-vesicles; and (3) genetically engineered vesicles. The synthesis of each VVS type and their corresponding properties that are advantageous for targeted drug delivery, are also highlighted. The applications, challenges, and limitations of VVS are briefly examined. Finally, we share a number of insights and perspectives regarding the future of VVS as a targeted drug delivery system at the nanoscale.
논문정보
- Review Paper
- 2024년 01월 (BRIC 등록일 2024-01-04)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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