한빛사논문
- 조회323
Hyun Sun Choi a, Jinyoung Yun a, Yeonsu Jeong a, Yun Kee Jo b,c, Hyung Joon Cha a,d
aDepartment of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea
bDepartment of Biomedical Convergence Science and Technology, School of Convergence, Kyungpook National University, Daegu 41566, Republic of Korea
cCell and Matrix Research Institute, Kyungpook National University, Daegu 41944, Republic of Korea
dMedical Science and Engineering, School of Convergence Science and Technology, Pohang University of Science, Pohang 37673, Republic of Korea
Corresponding authors: Yun Kee Jo, Hyung Joon Cha
Abstract
Periprosthetic infection is a devastating postimplantation complication in which a biofilm layer harboring invasive microorganisms forms around orthopedic implants, leading to severe implant failure and patient morbidity. Despite the development of several infection-triggered antibiotic release approaches, most current antibacterial coatings are susceptible to undesired antibiotic leakage or mechanical disintegration during prosthesis installation. Herein, we propose a self-controllable proteinic antibacterial coating capable of both long-lasting adherence onto titanium implant substrates over the implant fixation period and instantaneous bacterial eradication. Importantly, the pH-dependent reversible metal coordination of mussel adhesive protein (MAP) enabled bacterial concentration-dependent antibiotic delivery in response to infection-induced acidification. In addition, the MAP coating exhibited superior self-healable adhesive properties and scratch resistance, which enabled to avert issues associated with mechanical damages, including peeling and cracking, often occurring in conventional implant coating systems. The gentamicin-loaded MAP coating exhibited complete inhibition of bacterial growth in vivo against Staphylococcus aureus penetrations during implantation surgery (immediate infection) and even 4 weeks after implantation (delayed infection). Thus, our antibiotic-loaded MAP hydrogel coating can open new avenues for self-defensive antibiotic prophylaxis to achieve instant and sustainable bacteriocidal activity in orthopedic prostheses.
논문정보
- Research article
- 2023년 12월 (BRIC 등록일 2024-01-02)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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