한빛사논문
- 조회751
Ayoung Jeong a, Soo Jung Park b, Eun Jeong Lee b, Kyung Won Kim a
aDepartment of Life Science and Multidisciplinary Genome Institute, Hallym University, Chuncheon 24252, South Korea
bDepartment of Brain Science, Ajou University School of Medicine, Suwon 16499, South Korea
Corresponding authors : Eun Jeong Lee, Kyung Won Kim
Abstract
The increasing prevalence of nanoplastics in our environment due to the widespread use of plastics poses potential health risks that are not yet fully understood. This study examines the physiological and neurotoxic effects of these minuscule nanoplastic particles on the nematode Caenorhabditis elegans as well as on human cells. Here, we find that 25 nm polystyrene nanoplastic particles can inhibit animal growth and movement at very low concentrations, with varying effects on their surface groups. Furthermore, these nanoplastic particles not only accumulate in the digestive tract but also penetrate further into extraintestinal tissues. Such nanoplastics significantly compromise the integrity of the intestinal barrier, leading to “leaky gut” conditions and cause mitochondrial fragmentation in muscles, which possibly explains the observed movement impairments. A striking discovery was that these nanoplastics exacerbate symptoms similar to those of Parkinson’s disease (PD), including dopaminergic neuronal degeneration, locomotor dysfunction, and accumulation of α-Synuclein aggregates. Importantly, our study demonstrates that the detrimental effects of nanoplastics on the aggregation of α-Synuclein extend to both C. elegans and human cell models of PD. In conclusion, our research highlights the potential health hazards linked to the physicochemical properties of nanoplastics, underlining the urgency of understanding their interactions with biological systems.
논문정보
- Research article
- 2023년 12월 (BRIC 등록일 2023-12-29)
- 국내 연구진
- 생명과학 > 신경생물학
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