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조회480

양장우Jang Woo Yang

POSTECH

Adv. Mater., Dec 26 2023, | https://doi.org/10.1002/adma.202310338 A Customizable Proteinic Bioadhesive Patch with Water-Switchable Underwater Adhesiveness, Adjustable Biodegradability, and Modifiable Stretchability for Healing Diverse Internal Wounds

Jang Woo Yang ¹, Kang-Il Song ², Jaeyun Lee ¹, Sungho Park ³, Hyungkyu Huh ⁴, Geunho Choi ¹, Hwa Hui Shin ⁴, Hyung Joon Cha ^1,5

¹Department of Chemical Engineering, Pohang University of Science and Technology, 77 Cheongam-ro, Pohang, 37673, Republic of Korea.

²Division of Smart Healthcare, Pukyong National University, 45 Yongso-ro, Busan, 48513, Republic of Korea.

³Institute of Medical Devices, Kangwon National University, 1 Gangwondaehak-gil, Chuncheon, 24341, Republic of Korea.

⁴Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Cheombok-ro, Daegu, 41061, Republic of Korea.

⁵Medical Science and Engineering, School of Convergence Science and Technology, Pohang University of Science and Technology, 77 Cheongam-ro, Pohang, 37673, Republic of Korea.

CORRESPONDING AUTHORS : Hwa Hui Shin, Hyung Joon Cha

Abstract

Customizable bioadhesives for individual organ requirements, including tissue type and motion, are essential, especially given the rise in implantable medical device applications demanding adequate underwater adhesion. While synthetic bioadhesives are widely used, their toxicity upon degradation shifts focus to biocompatible natural biomaterials. However, enhancing the adhesive strengths of these biomaterials presents ongoing challenges while accommodating the unique properties of specific organs. To address these issues, three types of customized underwater bioadhesive patches (CUBAPs) with strong, water-responsive adhesion and controllable biodegradability and stretchability based on bioengineered mussel adhesive proteins conjugated with acrylic acid and/or methacrylic acid are proposed. The CUBAP system, although initially nonadhesive, shows strong underwater adhesion upon hydration, adjustable biodegradation, and adequate physical properties by adjusting the ratio of poly(acrylic acid) and poly(methacrylic acid). Through ex vivo and in vivo evaluations using defective organs and the implantation of electronic devices, the suitability of using CUBAPs for effective wound healing in diverse internal organs is demonstrated. Thus, this innovative CUBAP system offers strong underwater adhesiveness with tailored biodegradation timing and physical properties, giving it great potential in various biomedical applications.

논문정보

형식Research article
게재일2023년 12월 (BRIC 등록일 2023-12-29)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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