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정화준Hwajun Jeong

경희대학교

Coord. Chem. Rev., Available online 27 December 2023 | https://doi.org/10.1016/j.ccr.2023.215624 Recent advances in multifunctional therapeutic materials for overcoming cancer using light, ultrasound, and light-/ultrasound-induced immune system

Jaehoon Kim^a, Eun Woo Seo ^a, Jihyun Lee ^b, Jaehui Lee^c, Miyeon Jeong ^c, Hwajun Jeong ^d, Dokyoung Kim^{a,b,c,d,e,f,g}

^aDepartment of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

^bKHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea

^cDepartment of Precision Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

^dCollege of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea

^eCenter for Converging Humanities, Kyung Hee University, Seoul 02447, Republic of Korea

^fMedical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, Core Research Institute (CRI), Kyung Hee University, Seoul 02447, Republic of Korea

^gDepartment of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea

Corresponding authors : Hwajun Jeong, Dokyoung Kim

Abstract

Cancer is one of the most formidable diseases in modern society, and cancer treatment is facing a new phase. Alongside traditional methods such as chemotherapy, various practical adjuvant therapeutic approaches and related agents have been introduced to enhance the chances of a cure and reduce the recurrence of cancers. Notably, non-invasive external source-based therapeutic approaches, agents (sensitizers), and cancer-specific delivery materials using light (phototherapy), ultrasound, and light-/ultrasound-induced immune response have garnered widespread attention: (i) Photo: photodynamic therapy (PDT), photothermal therapy (PTT), (ii) Ultrasound: sonodynamic therapy (SDT), and (iii) Immune response: light-/ultrasound-induced immunotherapy (IMT). However, the application of the individual approach to cancer therapy exhibits some disadvantages and limitations despite their potential for developing a cure. In this comprehensive review, we have systematically summarized recent literature, focusing on the recent advances in multifunctional therapeutic materials, such as dual-functional, triple-functional, and all-in-one materials. We hope this review will inspire the development of next-generation multifunctional cancer therapeutic materials and thereby contribute to enhancing global health conditions.

논문정보

형식Review Paper
게재일2023년 12월 (BRIC 등록일 2024-01-09)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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