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J. Am. Chem. Soc., Dec 22 2023, | https://doi.org/10.1021/jacs.3c11092
Nanoscale Covalent Organic Framework with Staggered Stacking of Phthalocyanines for Mitochondria-Targeted Photodynamic Therapy
Jing Liu,1,2,#, DongWon Kang,1,3,#, Yingjie Fan,1, Geoffrey T. Nash,1, Xiaomin Jiang,1,2, Ralph R. Weichselbaum,2 and Wenbin Lin1,2,*
1Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States
2Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago, Chicago, Illinois 60637, United States
3Department of Chemistry and Chemical Engineering, Inha University, Incheon 22212, Republic of Korea
#These authors contributed equally.
Corresponding Author : Wenbin Lin
Abstract
Phthalocyanine photosensitizers (PSs) have shown promise in fluorescence imaging and photodynamic therapy (PDT) of malignant tumors, but their practical application is limited by the aggregation-induced quenching (AIQ) and inherent photobleaching of PSs. Herein, we report the synthesis of a two-dimensional nanoscale covalent organic framework (nCOF) with staggered (AB) stacking of zinc-phthalocyanines (ZnPc), ZnPc-PI, for fluorescence imaging and mitochondria-targeted PDT. ZnPc-PI isolates and confines ZnPc PSs in the rigid nCOF to reduce AIQ, improve photostability, enhance cellular uptake, and increase the level of reactive oxygen species (ROS) generation via mitochondrial targeting. ZnPc-PI shows efficient tumor accumulation, which allowed precise tumor imaging and nanoparticle tracking. With high cellular uptake and tumor accumulation, intrinsic mitochondrial targeting, and enhanced ROS generation, ZnPc-PI exhibits potent PDT efficacy with >95% tumor growth inhibition on two murine colon cancer models without causing side effects.
논문정보
- Research article
- 2023년 12월 (BRIC 등록일 2023-12-29)
- 국내+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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