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Small, Dec 24 2023, | https://doi.org/10.1002/smll.202310734
Osteoporotic Bone Regeneration via Plenished Biomimetic PLGA Scaffold with Sequential Release System
Jun-Kyu Lee 1, Da-Seul Kim 1,2, So-Yeon Park 1, Ji-Won Jung 1, Seung-Woon Baek 1, Semi Lee 1, Jun Hyuk Kim 1, Tae-Keun Ahn 3, Dong Keun Han 1
1Department of Biomedical Science, CHA University, 335 Pangyo-ro, Seongnam-si, Gyeonggi-do, 13488, Republic of Korea.
2Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Cambridge, MA, 02139, USA.
3Department of Orthopedic Surgery, CHA Bundang Medical Center, CHA University, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.
J.-K.L. and D.-S.K. contributed equally to this work.
CORRESPONDING AUTHORS : Tae-Keun Ahn, Dong Keun Han
Abstract
Achieving satisfactory bone tissue regeneration in osteoporotic patients with ordinary biomaterials is challenging because of the decreased bone mineral density and aberrant bone microenvironment. In addressing this issue, a biomimetic scaffold (PMEH/SP), incorporating 4-hexylresorcinol (4HR), and substance P (SP) into the poly(lactic-go-glycolic acid) (PLGA) scaffold with magnesium hydroxide (M) and extracellular matrix (E) is introduced, enabling the consecutive release of bioactive agents. 4HR and SP induced the phosphorylation of p38 MAPK and ERK in human umbilical vein endothelial cells (HUVECs), thereby upregulating VEGF expression level. The migration and tube-forming ability of endothelial cells can be promoted by the scaffold, which accelerates the formation and maturation of the bone. Moreover, 4HR played a crucial role in the inhibition of osteoclastogenesis by interrupting the IκB/NF-κB signaling pathway and exhibiting SP, thereby enhancing the migration and angiogenesis of HUVECs. Based on such a synergistic effect, osteoporosis can be suppressed, and bone regeneration can be achieved by inhibiting the RANKL pathway in vitro and in vivo, which is a commonly known mechanism of bone physiology. Therefore, the study presents a promising approach for developing a multifunctional regenerative material for sophisticated osteoporotic bone regeneration.
논문정보
- Research article
- 2023년 12월 (BRIC 등록일 2023-12-28)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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