한빛사논문
- 조회373
Woo-Sung Kim a,c, Jie Shen b,c, Uyanga Tsogt b,c, Soyolsaikhan Odkhuu b,c, Sahar Cheraghi b,c, Fatima Zahra Rami b,c, Young-Chul Chung a,b,c
aDepartment of Psychiatry, Jeonbuk National University Hospital, Jeonju, Korea
bMedical School, Department of Psychiatry, Jeonbuk National University, Jeonju, Korea
cResearch Institute of Clinical Medicine of Jeonbuk National, University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea
Corresponding author : Young-Chul Chung
Abstract
Background: Investigating neural correlates in recovered patients with psychosis is important in terms of identifying biological markers associated with recovery status or predicting a possible future relapse. We sought to examine thalamic nuclei volumes and thalamus-centered functional connectivity (FC) in recovered patients with psychosis who discontinued their medication.
Methods: Thirty patients with psychosis who satisfied the criteria for full recovery and 50 healthy controls (HC) matched for age, sex, and education underwent magnetic resonance imaging and clinical evaluation. The recovered patients were divided into the maintained and relapsed subjects according to their clinical status on the follow-ups. Thalamic nuclei volumes and thalamus-centered FC were measured between the recovered patients and HC. Correlations between the thalamic nuclei or altered FC, and clinical symptoms and cognitive functioning were explored.
Results: Modest cognitive impairments and reduced thalamic nuclei volumes were evident in the recovered patients. Moreover, we found altered thalamo-cortical connectivity and its associations with negative symptoms and cognitive functioning in the recovered patients compared with HC.
Conclusion: These findings suggest that there are still cognitive impairments, and aberrant neuronal changes in the recovered patients. The implication of differential FC patterns between the maintained and the relapsed patients remain to be further explored.
논문정보
- Research article
- 2023년 12월 (BRIC 등록일 2023-12-29)
- 국내 연구진
- 의약학 > 신경의학
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