Masato Tamari,^1,2,3,4,5,6 Kate L. Del Bel,⁷ Aaron M. Ver Heul,⁸ Lydia Zamidar,^1,2,3,4 Keisuke Orimo,⁶ Masato Hoshi,^9,10 Anna M. Trier,¹¹ Hiroshi Yano,^12,13,14 Ting-Lin Yang,¹¹ Catherine M. Biggs,⁷ Kenichiro Motomura,⁶ Rintaro Shibuya,^1,2,3,4 Chuyue D. Yu,^15,16 Zili Xie,^1,2,4 Hisato Iriki,^1,2,3,4 Zhen Wang,^1,2,3,4 Kelsey Auyeung,^1,2,3,4 Gargi Damle,^17,18 Deniz Demircioglu,^17,18 Jill K. Gregory,¹⁹ Dan Hasson,^17,18,20,21 Jinye Dai,^22,23 Rui B. Chang,^15,16,24 Hideaki Morita,^6,25 Kenji Matsumoto,⁶ Sanjay Jain,^9,10 Steven Van Dyken,⁹ Joshua D. Milner,²⁶ Dusan Bogunovic,^{3,17,20,27,28,29,30} Hongzhen Hu,^1,2,4 David Artis,^{12,13,14,24,31} Stuart E. Turvey,⁷ and Brian S. Kim ^{1,2,3,4,24,32,*}

¹Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

²Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

³Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

⁴Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

⁵Department of Pediatrics, Jikei University School of Medicine, Minato-ku, Tokyo 1058471, Japan

⁶Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo 1578535, Japan

⁷Department of Pediatrics, British Columbia Children’s Hospital, University of British Columbia, Vancouver, BC V5Z 4H4, Canada

⁸Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA

⁹Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA

¹⁰Division of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA

¹¹Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA

¹²Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA

¹³Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA

¹⁴Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA

¹⁵Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA

¹⁶Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA

¹⁷Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) Core, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

¹⁸Skin Biology and Disease Resource-based Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

¹⁹Digital and Technology Partners, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

²⁰Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

²¹Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

²²Department of Pharmacological Science, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

²³Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

²⁴Allen Discovery Center for Neuroimmune Interactions, New York, NY 10029, USA

²⁵Allergy Center, National Center for Child Health and Development, Setagaya-ku, Tokyo 1578535, Japan

²⁶Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA

²⁷Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

²⁸Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

²⁹Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

³⁰Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

³¹Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA

³²Lead contact

^*Corresponding author: correspondence to Brian S. Kim