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Adv. Healthc. Mater., Dec 20 2023, | https://doi.org/10.1002/adhm.202303563 Soft Bioelectronics for Neuroengineering: New Horizons in the Treatment of Brain Tumor and Epilepsy

Seungwon Yoo ^1,2⊥, Minjeong Kim^1,2⊥, Changsoon Choi ³, Dae-Hyeong Kim ^1,2,4*, Gi Doo Cha^5*

¹Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea.

²School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea.

³Center for Opto-Electronic Materials and Devices, Post-silicon Semiconductor Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.

⁴Department of Materials Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea.

⁵Department of Systems Biotechnology, Chung-Ang University, Anseong-si, Gyeonggi-do, 17546, Republic of Korea.

^⊥These authors equally contributed to this work.

^*CORRESPONDING AUTHORS : Dae-Hyeong Kim, Gi. Doo Cha

Abstract

Soft bioelectronic technologies for neuroengineering have shown remarkable progress, which include novel soft material technologies and device design strategies. Such technological advances that were initiated from fundamental brain science have recently been applied to clinical neuroscience and provided meaningful promises for significant improvement in the diagnosis efficiency and therapeutic efficacy of various brain diseases. System-level integration strategies in consideration of specific disease circumstances could enhance treatment effects further. Here, we review recent advances in soft implantable bioelectronics for neuroengineering, focusing on materials and device designs optimized for the treatment of intracranial disease environments. We first categorize and exemplify various types of soft bioelectronics for neuroengineering, and then explain details for the sensing and stimulating device components. Next, we review application examples of soft implantable bioelectronics to clinical neuroscience, particularly focusing on the treatment of brain tumor and epilepsy. Finally, we present an ideal system of the soft intracranial bioelectronics such as closed-loop-type fully-integrated systems, and discuss the remaining challenges for their clinical translation. This article is protected by copyright. All rights reserved.

논문정보

형식Review Paper
게재일2023년 12월 (BRIC 등록일 2023-12-21)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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