한빛사논문
Kyungtae Park a,1, Sungwon Jung a,1, Hye-Jin Lee b,1, Hyangsu Nam c, Sungeun Heo a, Yoogyeong Oh a, Chai Won Park b, Jungbum Kim b, June Hong Ahn d, Jong Bum Lee c, Patrick T.J. Hwang e, Sangmin Lee f, Wonhwa Lee b, Jinkee Hong a
aSchool of Chemical & Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea
bDepartment of Chemistry, Sungkyunkwan University, Suwon 16419, Republic of Korea
cDepartment of Chemical Engineering, University of Seoul, Seoul 02504, Republic of Korea
dDivision of Pulmonology and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center, Daegu 42415, Republic of Korea
eThe Cardiovascular Institute and the Department of Biomedical Engineering in the Rowan-Virtua School of Translational Biomedical Engineering & Sciences, Glassboro, NJ 08028, United States
fSchool of Mechanical Engineering, Chung-ang University, 84, Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea
1These authors contributed equally to this work.
Corresponding authors : Sangmin Lee, Wonhwa Lee, Jinkee Hong
Abstract
Among patients who suffer from lung-related disability, acute respiratory distress syndrome (ARDS) is one of the diseases with the significant mortality rate and the main cause is the interference in pulmonary drug delivery by accumulated bronchoalveolar lavage fluid (BALF) in the alveolar region. Here, a zwitterion-functionalized multi-drug nanocomplex (ZnC) capable of anti-mucociliary clearance was synthesized. Additionally, nitric oxide (NO) was functionalized with ZnC to fuel the mobility in the BALF through its role as a nanomotor as well as anti-inflammation. Subsequently, dexamethasone (Dex) was loaded and final product of anti-inflammatory mucus permeator (AIM) was introduced. By in situ tracking the AIM within the mucus-rich environment, the fueled mobility by NO and zwitterion was demonstrated. Notably, when AIM was inhaled by the in vivo ARDS model, there was an increase in the anti-inflammation effect due to the presence of ZnC as well as the synergy between NO and Dex, which recovered the pulmonary function of the model and increased survival rate.
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