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Hepatology, Nov 01 2023, | https://doi.org/10.1097/HEP.0000000000000664 Prevalence, distribution and hepatic fibrosis burden of the different subtypes of steatotic liver disease in primary care settings

Lee, Chul-min¹; Yoon, Eileen L.^2,3; Kim, Mimi¹; Kang, Bo-Kyeong¹; Cho, Seon⁴; Nah, Eun-Hee⁴; Jun, Dae Won^2,3

¹Department of Radiology, Hanyang University College of Medicine, Seoul, Korea

²Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea

³Hanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul, Korea

⁴Department of Laboratory Medicine, Health Promotion Research Institute, Seoul, Korea

C. Lee and Eileen L. Yoon contributed equally to this work as co-first authors.

Correspondence Dae Won Jun

Abstract

Background and aim: In relation to the new umbrella terminology for steatotic liver disease (SLD), we aimed to elucidate the prevalence, distribution and clinical characteristics of the SLD subgroups in the primary care setting.

Approach and method: We retrospectively collected data from 2,535 individuals who underwent magnetic resonance imaging elastography (MRE) and proton density fat fraction (MRI-PDFF) during health check-ups in five primary care health promotion clinics. We evaluated the presence of cardiometabolic risk factors according to predefined criteria and divided all the participants according to the new SLD classification.

Result and conclusion: The prevalence of SLD was 39.13% in the total cohort, and 95.77% of the SLD cases had metabolic dysfunction (one or more cardiometabolic risk factors). The prevalence of metabolic dysfunction associated steatotic liver disease (MASLD) was 29.51%, with those of metabolic dysfunction and increased alcohol intake (MetALD) and alcohol-associated liver disease (ALD) at 7.89% and 0.39%, respectively. According to the old criteria, the prevalence of non-alcoholic fatty liver disease (NAFLD) was 29.11%, and 95.80% of the NAFLD cases fulfilled the new criteria for MASLD. The distribution of SLD subtypes was highest for MASLD, at 75.40%, followed by MetALD at 20.06%, cryptogenic SLD at 3.33%, and ALD at 1.01%. The MetALD group had a significantly higher mean MRE than the MASLD or ALD group. Almost all the NAFLD patients met the new criteria for MASLD. The fibrosis burden of the MetALD group was higher than those of the MASLD and ALD groups.

논문정보

형식Research article
게재일2023년 11월 (BRIC 등록일 2023-12-18)
연구진국내 연구진
분야 의약학 > 응용의학

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