한빛사논문
- 조회517
Min Jun Shin 1*, Jun-Young Park 1,2*, Jun Young Park 1*, Su Hyun Lim 1*, Hyoungsub Lim 2*, Jin Kyeong Choi 3, Chul-Kyu Park 1,2,4, Youn Joo Kang 5†, Dongwoo Khang 1,2,4,6†
1Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, 21999, South Korea.
2Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 21999, South Korea.
3Department of Immunology, School of Medicine, Jeonbuk National University, Jeonju, 54907, South Korea.
4Department of Physiology, School of Medicine, Gachon University, Incheon, 21999, South Korea.
5Department of Rehabilitation Medicine, Eulji Hospital, School of Medicine, Eulji University, Seoul, 01830, South Korea.
6Ectosome Inc., Incheon, 21999, South Korea.
*These authors contributed equally to this work.
†Corresponding authors: Prof. Dongwoo Khang, Prof. Youn Joo Kang
Abstract
Current clinical therapeutic efficacy for the treatment of osteo- and rheumatoid-arthritis is obviously limited. Although mesenchymal stem cells (MSCs) are considered as a source of promising regenerative therapy, un-modified MSCs or genetically engineered MSCs injected in vivo restrict their clinical utility because of the low drug efficacy and unpredicted side effect, respectively. Herein, a strategy to enhance the migration efficacy of MSCs to inflamed joints via an inflammation-mediated education process was demonstrated. To reinforce the limited anti-inflammatory activity of MSCs, gold nano-star loaded with triamcinolone are conjugated to MSC. Furthermore, near-infrared laser-assisted photothermal therapy (PTT) induced by gold nano-star significantly elevate the anti-inflammatory efficacy of the developed drugs, even in advanced stage arthritis model. An immunological regulation mechanism study of PTT is first suggested in this study; the expression of the interleukin 22 receptor, implicated in the pathogenesis of arthritis, was downregulated in T lymphocytes by PTT, and Th17 differentiation from naïve CD4 T cell was inhibited. Collectively, inflammation-targeting MSCs conjugated with triamcinolone-loaded gold nano-star promote the repolarization of macrophages and decrease neutrophil recruitment in joints. In addition, Edu-MSCs-AuS-TA significantly alleviate arthritis-associated pain and improve general locomotor activity, and more importantly, induced cartilage regeneration even for severe stages of arthritis model.
논문정보
- Research article
- 2023년 12월 (BRIC 등록일 2023-12-15)
- 국내 연구진
- 의약학 > 약학
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