김진식 (동국대학교)

한빛사논문

조회329

김진식Jinsik Kim

동국대학교

CV File 145 kb

Biosens. Bioelectron., Nov 30 2023, 246 S0956-5663(23)00809-6 | https://doi.org/10.1016/j.bios.2023.115867 Dielectrophoretic force-induced wrinkling of graphene oxide: Enhancing electrical conductivity and expanding biosensing applications

Yejin Park^a, Hyejin Kim^b,c, Jaeyoon Song ^a, Sehyeon Kim^a, Byung Chul Lee ^d,e, Jinsik Kim^a

^aDepartment of Biomedical Engineering, College of Life Science and Biotechnology, Dongguk University, Seoul 04620, Republic of Korea

^bInstitute of Chemical Processes (ICP), Seoul National University, Seoul 08826, Republic of Korea

^cCenter for Nanoparticle Research, Institute for Basic Science (IBS), Seoul National University, Seoul 08826, Republic of Korea

^dBionics Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Korea

^eKHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, 02447, Korea

Corresponding author : Jinsik Kim

Abstract

Graphene oxide (GO) has many advantages, making it suitable for various applications. However, it has low electrical conductivity, restricting its applicability to electrochemical biosensors. This study used dielectrophoretic (DEP) force to control the movement and deformation of GO nanosheets to achieve high electrical conductivity without the chemical reduction of oxygen functional groups. Subjecting the DEP force to GO nanosheets induced physical deformation leading to the formation of wrinkled structures. A computational simulation was performed to set an appropriate electrical condition for operating a positive DEP force effect of at least 10 ¹⁹ v ²/m ³, and the interdigitated microelectrode structure was selected. The resulting wrinkled GO exhibited significantly improved electrical conductivity, reaching 21.721 μS while preserving the essential oxygen functional groups. Furthermore, a biosensor was fabricated using wrinkled GO deposited via DEP force. The biosensor demonstrated superior sensitivity, exhibiting a 9.6-fold enhancement compared with reduced GO (rGO) biosensors, as demonstrated through biological experiments targeting inducible nitric oxide synthase. This study highlights the potential of using DEP force to enhance electrical conductivity in GO-based biosensing applications, opening new avenues for high-performance diagnostics.

논문정보

형식Research article
게재일2023년 11월 (BRIC 등록일 2023-12-14)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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