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성균관대학교

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J. Control. Release, Dec 09 2023, S0168-3659(23)00791-5 | https://doi.org/10.1016/j.jconrel.2023.12.007 Nanoparticle-based immunoengineering strategies for enhancing cancer immunotherapy

Bao-Toan Nguyen Dang ^a, Taeg Kyu Kwon ^b, Sooyeun Lee ^a, Jee-Heon Jeong ^c, Simmyung Yook^d,e

^aCollege of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea

^bDepartment of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea

^cDepartment of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea

^dDepartment of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea

^eSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea

Corresponding authors: Jee-Heon Jeong, Simmyung Yook

Abstract

Cancer immunotherapy is a groundbreaking strategy that has revolutionized the field of oncology compared to other therapeutic strategies, such as surgery, chemotherapy, or radiotherapy. However, cancer complexity, tumor heterogeneity, and immune escape have become the main hurdles to the clinical application of immunotherapy. Moreover, conventional immunotherapies cause many harmful side effects owing to hyperreactivity in patients, long treatment durations and expensive cost. Nanotechnology is considered a transformative approach that enhances the potency of immunotherapy by capitalizing on the superior physicochemical properties of nanocarriers, creating highly targeted tissue delivery systems. These advantageous features include a substantial specific surface area, which enhances the interaction with the immune system. In addition, the capability to finely modify surface chemistry enables the achievement of controlled and sustained release properties. These advances have significantly increased the potential of immunotherapy, making it more powerful than ever before. In this review, we introduce recent nanocarriers for application in cancer immunotherapy based on strategies that target different main immune cells, including T cells, dendritic cells, natural killer cells, and tumor-associated macrophages. We also provide an overview of the role and significance of nanotechnology in cancer immunotherapy.

논문정보

형식Review Paper
게재일2023년 12월 (BRIC 등록일 2023-12-18)
연구진국내 연구진
분야 의약학 > 약학

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