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조회183

노태현Taehyun Roh

Texas A&M University

Environ. Int., Nov 15 2023, 183 S0160-4120(23)00602-5 | https://doi.org/10.1016/j.envint.2023.108329 Association of arsenic exposure with measles antibody titers in US children: Influence of sex and serum folate levels

Taehyun Roh ^a, Annette K. Regan ^b, Natalie M. Johnson ^c, Nishat Tasnim Hasan ^a, Nusrat Fahmida Trisha ^a, Anisha Aggarwal ^d, Daikwon Han^a

^aDepartment of Epidemiology and Biostatistics, School of Public Health, Texas A&M University, College Station, TX 77843, USA

^bSchool of Nursing and Health Professions, University of San Francisco, San Francisco, CA 94117, USA

^cDepartment of Environmental and Occupational Health, School of Public Health, Texas A&M University, College Station, TX 77843, USA

^dDepartment of Health Behavior, School of Public Health, Texas A&M University, College Station, TX 77843, USA

Corresponding author : Taehyun Roh

Abstract

Exposure to arsenic during childhood is associated with various adverse health conditions. However, little is known about the effect of arsenic exposure on vaccine-related humoral immunity in children. We analyzed data from the National Health and Nutrition Examination Survey (2003-2004 and 2009-2010) to study the relationship between urinary arsenic and measles antibody levels in 476 US children aged 6-11. Multivariable linear regression was used to evaluate the association, adjusting for cycle, age, race, body mass index (BMI), serum cotinine, poverty index ratio, and vitamin B12 and selenium intakes. Stratified analyses were conducted by sex and serum folate levels using the median as cutoff (18.7 ng/mL). The measles antibody concentrations in the 3rd and 4th quartiles were found to have significantly decreased by 28.5 % (95 % Confidence Interval (CI) -47.6, -2.28) and 36.8 % (95 % CI -50.2, -19.5), compared to the lowest quartile among boys with serum folate levels lower than 18.7 ng/ml. The serum measles antibody titers significantly decreased by 16.7 % (95 %CI -25.0, -7.61) for each doubling of creatinine-corrected urinary total inorganic arsenic concentrations in the same group. No associations were found in boys with high serum folate levels or in girls. Further prospective studies are needed to validate these findings and develop interventions to protect children from infectious diseases.

논문정보

형식Research article
게재일2023년 11월 (BRIC 등록일 2024-03-07)
연구진국외 연구진
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