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한빛사논문
한빛사논문
- 조회314
Biomaterials, Volume 304, January 2024, 122419 | https://doi.org/10.1016/j.biomaterials.2023.122419
Endogenous CO imaging in bacterial pneumonia with a NIR fluorescent probe
Beitong Zhu a, Xuejian Xing b, Jungryun Kim c, Hyeonji Rha c, Chun Liu d, Qiang Zhang d, Lintao Zeng a, Minhuan Lan b, Jong Seung Kim c
aSchool of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi, 530004, China
bKey Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, China
cDepartment of Chemistry, Korea University, Seoul, 02841, South Korea
dDepartment of Respirology & Critical Care Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410083, China
Corresponding authors: Lintao Zeng, Minhuan Lan, Jong Seung Kim
Abstract
Bacterial pneumonia is a serious respiratory illness that poses a great threat to human life. Rapid and precise diagnosis of bacterial pneumonia is crucial for symptomatic clinical treatment. Endogenous carbon monoxide (CO) is regarded as a significant indicator of bacterial pneumonia; herein, we developed a near-infrared (NIR) probe for fluorescence and photoacoustic (PA) dual-mode imaging of endogenous CO in bacterial pneumonia. NO
2-BODIPY could rapidly and specifically react with CO to produce strong NIR fluorescence as well as ratiometric PA signals. NO
2-BODIPY has outstanding features including fast response, fluorescence/PA dual mode signals, good specificity, and a low limit of detection (LOD = 20.3 nM), which enables it to image endogenous CO in cells and bacterial pneumonia mice with high sensitivity and high contrast ratio. In particular, NO
2-BODIPY has two-photon excited (1340 nm, σ
1 = 1671 GM) NIR fluorescence and has been utilized to image endogenous CO in bacterial pneumonia mice with deep tissue penetration. NO
2-BODIPY has been demonstrated a good capability of fluorescence/PA dual-mode imaging of CO in bacterial pneumonia mice, providing a precise manner to diagnose bacterial pneumonia.
논문정보
- Research article
- 2024년 01월 (BRIC 등록일 2023-12-14)
- 국내(교신)+국외 연구진
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