한빛사논문
- 조회614
Won‑Kyu Rhim†, Jun Yong Kim1,2,3†, Seung Yeon Lee1, Seung‑Gyu Cha1, Jeong Min Park1, Hyeon Jeong Park1, Chun Gwon Park2,3 and Dong Keun Han1*
1Department of Biomedical Science, CHA University, 335 Pangyo‑ro Bun‑dang‑gu, Seongnam‑si, Gyeonggi‑do 13488, Republic of Korea.
2Department of Biomedical Engineering, 2066 Seobu‑ro Jangan‑gu, Suwon‑si, Gyeonggi‑do 16419, Republic of Korea.
3Intelligent Precision of Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), 2066 Seobu‑ro Jangan‑gu, Suwon‑si, Gyeonggi‑do 16419, Republic of Korea.
†Won-Kyu Rhim and Jun Yong Kim equally contributed to this work.
*Correspondence: Dong Keun Han
Abstract
Extracellular vesicles (EVs) are nanosized particles that are released from cells and reflect the characteristics of the mother cell. Recently, the EVs have been used in several types of studies across many different fields. In the field of EV research, multiple cell culture and EV isolation techniques have been highlighted in importance. Various strategies, including exclusive component culture media, three-dimensional (3D) cultures, and hypoxic conditions, have been proposed for the cell culture to control function of the EVs. Ultracentrifugation, ultrafiltration, precipitation, and tangential flow filtration (TFF) have been utilized for EV isolation. Although isolated EVs have their own functionalities, several researchers are trying to functionalize EVs by applying various engineering approaches. Gene editing, exogenous, endogenous, and hybridization methods are the four well-known types of EV functionalization strategies. EV engineered through these processes has been applied in the field of regenerative medicine, including kidney diseases, osteoarthritis, rheumatoid arthritis, nervous system-related diseases, and others. In this review, it was focused on engineering approaches for EV functionalization and their applications in regenerative medicine.
논문정보
- Review Paper
- 2023년 12월 (BRIC 등록일 2023-12-12)
- 국내 연구진
- 바이오·의료융합 > 바이오·의료융합 기타
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