한빛사논문
- 조회608
Kyeonghun Lee 1, Hayeon Lee 2,3, Rosie Kwon 3, Youn Ho Shin 3, Seung Geun Yeo 4, Young Joo Lee 5, Min Seo Kim 6, Yong Sung Choi 7, Nikolaos G Papadopoulos 8,9, Masoud Rahmati 10,11, Junyang Jung 12, Jinseok Lee 2, Dong Keon Yon 3,7
1Department of Pediatrics, Chung-Ang University Hospital, Seoul, South Korea.
2Department of Biomedical Engineering, Kyung Hee University College of Electronics and Information, Yongin, South Korea.
3Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea.
4Department of Otolaryngology - Head & Neck Surgery, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
5Department of Obstetrics and Gynecology, Kyung Hee University College of Medicine, Seoul, South Korea.
6Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
7Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
8Allergy Department, 2nd Paediatric Clinic, National Kapodistrian University of Athens, Athens, Greece.
9Lydia Becker Institute of Immunology & Inflammation, University of Manchester, Manchester, UK.
10Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.
11Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran.
12Department of Anatomy and Neurobiology, Kyung Hee University College of Medicine, Seoul, South Korea.
Kyeonghun Lee, Hayeon Lee and Rosie Kwon contributed equally to this work.
Junyang Jung, Jinseok Lee and Dong Keon Yon contributed equally to this work.
CORRESPONDING AUTHOR : Dong Keon Yon
Abstract
Background: Vaccine-associated anaphylaxis is a rare but life-threatening reaction that occurs within minutes to hours of exposure to allergens. As studies utilizing large-scale data to investigate this topic are limited, further research is needed to assess its burden, long-term trends, and associated risk factors so as to gain a comprehensive understanding of vaccine-associated anaphylaxis globally. Therefore, this study aimed to investigate the global burden of vaccine-associated anaphylaxis and related vaccines.
Method: This study utilized the World Health Organization International Pharmacovigilance Database, in which reports of vaccine-associated anaphylaxis between 1967 and 2023 were obtained (total reports = 131,255,418). We estimated the global reporting counts, reported odds ratio (ROR), and information component (IC) to identify the relationship between 19 vaccines and associated anaphylaxis in 156 countries and territories.
Results: We identified 31,676 reports of vaccine-associated anaphylaxis among 363,290 reports of all-cause anaphylaxis. The cumulative number of reports on vaccine-associated anaphylaxis has gradually increased over time, with a dramatic increase after 2020, owing to reports of COVID-19 mRNA vaccine-associated anaphylaxis. The typhoid vaccines were associated with the most anaphylactic reports (ROR: 4.35; IC0.25 : 1.86), followed by encephalitis (3.27; 1.45), hepatitis B (2.69; 1.30), cholera (2.65; 0.54), hepatitis A (2.44; 1.12), influenza (2.36; 1.16), inactivated whole-virus COVID-19 (2.21; 1.02), and COVID-19 mRNA vaccines (1.89; 0.79). In terms of age- and sex-specific risks, vaccine-associated anaphylaxis reports develop more frequently in females and at young ages. The Ad5-vectored COVID-19 vaccine anaphylaxis reports were associated with the highest fatality rate (15.0%).
Conclusions: Although multiple vaccines are associated with various spectra and risks of anaphylaxis, clinicians should recognize the possibility of anaphylaxis occurring with all vaccines, particularly the COVID-19 mRNA and inactivated whole-virus COVID-19 vaccines, and consider the risk factors associated with vaccine anaphylaxis reports. Further studies are warranted to identify better ways of preventing vaccine-associated anaphylaxis.
논문정보
- Research article
- 2023년 12월 (BRIC 등록일 2023-12-11)
- 국내(교신)+국외 연구진
- 의약학 > 면역의학
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