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ACS Nano, Dec 07 2023, | https://doi.org/10.1021/acsnano.3c08840 Second Skin as Self-Protection Against γ-Hydroxybutyrate

Gyeong-Ji Kim ¹, Seon Joo Park ², Lina Kim², Kyung Ho Kim ², Soomin Kim ², Jai Eun An ¹, Chan Jae Shin ¹, Sung Eun Seo ², Seongjae Jo ², Jinyeong Kim ², Siyoung Ha ³, Hwi Won Seo², Mun-Chual Rho ⁴, Do Hyung Kwon ^5,6, Woo-Keun Kim ⁷, Gugin Jeong ⁸, Jae Chun Ryu ⁸, Jae Joon Kim⁹, Oh Seok Kwon^1,10,11

¹SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

²Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.

³Department of Pharmacy, University of Maryland Eastern Shore, Princess Anne, Maryland 21853, United States.

⁴Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup 56212, Republic of Korea.

⁵Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.

⁶Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon 34113, Republic of Korea.

⁷Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.

⁸BJ BIOCHEM, Inc., Daejeon 34025, Republic of Korea.

⁹Flexible Electronics Research Section, Reality Devices Research Division, Hyper-Reality Metaverse Research Laboratory, Electronics and Telecommunications Research Institute (ETRI), Daejeon 34129, Republic of Korea.

¹⁰Department of Nano Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

¹¹Department of Nano Science and Technology, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

G.-J.K. and S.J.P. contributed equally to this work.

Corresponding Authors : Jae Joon Kim, Oh Seok Kwon

Abstract

γ-Hydroxybutyrate (GHB), a date-rape drug, causes certain symptoms, such as amnesia, confusion, ataxia, and unconsciousness, when dissolved in beverages and consumed by a victim. Commonly, assailants use GHB in secret for the crime of drug-facilitated sexual assault because it is tasteless, odorless, and colorless when dissolved in beverages. Generally, GHB detection methods are difficult to use promptly and secretly in situ and in real life because of the necessary detection equipment and low selectivity. To overcome this problem, we have developed a fast, simple, and easy-to-use second skin platform as a confidential self-protection platform that can detect GHB in situ or in real life without equipment. The second skin platform for naked-eye detection of GHB is fabricated with poly(vinyl alcohol) (PVA), polyurethane (PU), and polyacrylonitrile (PAN) included in the chemical receptor 2-(3-bromo-4-hydroxystyryl)-3-ethylbenzothiazol-3-ium iodide (BHEI). PAN conjugated with BHEI nanofibers (PB NFs) has various characteristics, such as ease of use, high sensitivity, and fast color change. PB NFs rapidly detected GHB at 0.01 mg/mL. Furthermore, the second-skin platform attached to the fingertip and wrist detected both 1 and 0.1 mg/mL GHB in solution within 50 s. The color changes caused by the interaction of GHB and the second skin platform cannot be stopped due to strong chemical reactions. In addition, a second skin platform can be secretly utilized in real life because it can recognize fingerprints and object temperatures. Therefore, the second skin platform can be used to aid daily life and prevent drug-facilitated sexual assault crime when attached to the skin because it can be exposed anytime and anywhere.

논문정보

형식Research article
게재일2023년 12월 (BRIC 등록일 2023-12-08)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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