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- 조회509
Small, Dec 06 2023, | https://doi.org/10.1002/smll.202308936
Inhalable Nitric Oxide Delivery Systems for Pulmonary Arterial Hypertension Treatment
Yoogyeong Oh 1, Kyungtae Park 1, Sungwon Jung 1, Moonhyun Choi 1, Taihyun Kim 1, Yoojin Lee 1, Jae Young Choi 2, Yang-Hee Kim 3, Se Yong Jung 2, Jinkee Hong 1
1School of Chemical & Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
2Division of Pediatric Cardiology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
3Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK.
CORRESPONDING AUTHORS : Yang-Hee Kim, Se Yong Jung, Jinkee Hong
Abstract
Pulmonary arterial hypertension (PAH) is a severe medical condition characterized by elevated blood pressure in the pulmonary arteries. Nitric oxide (NO) is a gaseous signaling molecule with potent vasodilator effects; however, inhaled NO is limited in clinical practice because of the need for tracheal intubation and the toxicity of high NO concentrations. In this study, inhalable NO-releasing microspheres (NO inhalers) are fabricated to deliver nanomolar NO through a nebulizer. Two NO inhalers with distinct porous structures are prepared depending on the molecular weights of NO donors. It is confirmed that pore formation can be controlled by regulating the migration of water molecules from the external aqueous phase to the internal aqueous phase. Notably, open porous NO inhalers (OPNIs) can deliver NO deep into the lungs through a nebulizer. Furthermore, OPNIs exhibit vasodilatory and anti-inflammatory effects via sustained NO release. In conclusion, the findings suggest that OPNIs with highly porous structures have the potential to serve as tools for PAH treatment.
논문정보
- Research article
- 2023년 12월 (BRIC 등록일 2023-12-07)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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