변민지 (성균관대학교)

한빛사논문

조회368

성균관대학교

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Small, Dec 05 2023, | https://doi.org/10.1002/smll.202304862 Biofunctional Inorganic Layered Double Hydroxide Nanohybrid Enhances Immunotherapeutic Effect on Atopic Dermatitis Treatment

Min Ji Byun ^1,2, Hee Seung Seo ^1,2, Joonghak Lee ³, Kitae Ban ³, Serim Oh ³, Yun Young Lee ^1,4, Jaesung Lim ^1,2, Na Kyeong Lee ^1,2, Chi-Pin James Wang ^1,2, Minjeong Kim ^1,2, Jun-Hyeok Han ^2,5, Juwon Park ⁶, Taejong Paik ⁷, Hee Ho Park⁸, Tae-Eun Park ⁹, Wooram Park ^5,10, Se-Na Kim ^11,12, Dae-Hwan Park ^3,12,13,14, Chun Gwon Park ^1,2,10,15

¹Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.

²Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.

³Department of Engineering Chemistry, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea.

⁴Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.

⁵Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.

⁶Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School Medicine, University of Hawai'i at Manoa, Honolulu, Hawaii, 96813, USA.

⁷School of Integrative Engineering, Chung-Ang University, Seoul, 06974, Republic of Korea.

⁸Department of Bioengineering, Hanyang University, Seoul, 04763, Republic of Korea.

⁹Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.

¹⁰Biomaterials Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.

¹¹Research and Development Center, MediArk Inc., Cheongju, Chungbuk, 28644, Republic of Korea.

¹²Department of Industrial Cosmetic Science, College of Bio-Health University System, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea.

¹³Department of Synchrotron Radiation Science and Technology, College of Bio-Health University System, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea.

¹⁴LANG SCIENCE Inc, Cheongju, Chungbuk, 28644, Republic of Korea.

¹⁵Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU), Suwon, Gyeonggi, 16419, Republic of Korea.

CORRESPONDING AUTHORS : Se-Na Kim, Dae-Hwan Park, Chun Gwon Park

Abstract

Atopic dermatitis (AD) is a widespread, recurrent, and chronic inflammatory skin condition that imposes a major burden on patients. Conventional treatments, such as corticosteroids, are associated with various side effects, underscoring the need for innovative therapeutic approaches. In this study, the possibility of using indole-3-acetic acid-loaded layered double hydroxides (IAA-LDHs) is evaluated as a novel treatment for AD. IAA is an auxin-class plant hormone with antioxidant and anti-inflammatory effects. Following the synthesis of IAA-LDH nanohybrids, their ability to induce M2-like macrophage polarization in macrophages obtained from mouse bone marrow is assessed. The antioxidant activity of IAA-LDH is quantified by assessing the decrease in intracellular reactive oxygen species levels. The anti-inflammatory and anti-atopic characteristics of IAA-LDH are evaluated in a mouse model of AD by examining the cutaneous tissues, immunological organs, and cells. The findings suggest that IAA-LDH has great therapeutic potential as a candidate for AD treatment based on its in vitro and in vivo modulation of AD immunology, enhancement of macrophage polarization, and antioxidant activity. This inorganic drug delivery technology represents a promising new avenue for the development of safe and effective AD treatments.

논문정보

형식Research article
게재일2023년 12월 (BRIC 등록일 2024-01-04)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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