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Ngoc Man PhanNgoc Man Phan

성균관대학교

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ACS Nano, Dec 05 2023, | https://doi.org/10.1021/acsnano.3c04497 ROS-Scavenging Lignin-Based Tolerogenic Nanoparticle Vaccine for Treatment of Multiple Sclerosis

Ngoc Man Phan ¹, Thanh Loc Nguyen¹, Hyunsu Shin ¹, Thuy An Trinh ¹, Jaeyun Kim ^1,2,3,4

¹School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

²Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

³Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

⁴Institute of Quantum Biophysics (IQB), Sungkyunkwan University, Suwon 16419, Republic of Korea.

N.M.P. and T.L.N. contributed equally to this work.

Corresponding Author : Jaeyun Kim

Abstract

Multiple sclerosis (MS) is a demyelinating autoimmune disease, in which the immune system attacks myelin. Although systemic immunosuppressive agents have been used to treat MS, long-term treatment with these drugs causes undesirable side effects such as altered glucose metabolism, insomnia, and hypertension. Herein, we propose a tolerogenic therapeutic vaccine to treat MS based on lignin nanoparticles (LNP) with intrinsic reactive oxygen species (ROS)-scavenging capacity derived from their phenolic moieties. The LNP loaded with autoantigens of MS allowed for inducing tolerogenic DCs with low-level expression of costimulatory molecules while presenting antigenic peptides. Intravenous injection of an LNP-based tolerogenic vaccine into an experimental autoimmune encephalomyelitis (EAE) model led to durable antigen-specific immune tolerance via inducing regulatory T cells (Tregs). Autoreactive T helper type 1 cells, T helper type 17 cells, and inflammatory antigen presentation cells (APCs) were suppressed in the central nervous system (CNS), ameliorating ongoing MS in early and late disease states. Additionally, the incorporation of dexamethasone into an LNP-based tolerogenic nanovaccine could further improve the recovery of EAE mice in the severe chronic stage. As lignin is the most abundant biomass and waste byproduct in the pulping industry, a lignin-based tolerogenic vaccine could be a novel, cost-effective, high-value vaccine platform with potent therapeutic efficiency in treating autoimmune diseases.

논문정보

형식Research article
게재일2023년 12월 (BRIC 등록일 2023-12-06)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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