James J. Moon (University of Michigan) | 한빛사논문 > 한빛사

한빛사논문

조회280

University of Michigan

Adv. Drug Deliv. Rev., Nov 18 2023, 203 S0169-409X(23)00455-6 | https://doi.org/10.1016/j.addr.2023.115140 Vaccines for immune tolerance against autoimmune disease

April Kim^a,b,1, Fang Xie ^a,b,1, Omar A. Abed ^b,c, James J. Moon ^a,b,c,d

^aDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA

^bBiointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA

^cDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA

^dDepartment of Biomedical Engineering, University of Michigan, Ann Arbor 48109, USA

¹Authors contributed equally.

Corresponding author : James J. Moon

Abstract

The high prevalence and rising incidence of autoimmune diseases have become a prominent public health issue. Autoimmune disorders result from the immune system erroneously attacking the body's own healthy cells and tissues, causing persistent inflammation, tissue injury, and impaired organ function. Existing treatments primarily rely on broad immunosuppression, leaving patients vulnerable to infections and necessitating lifelong treatments. To address these unmet needs, an emerging frontier of vaccine development aims to restore immune equilibrium by inducing immune tolerance to autoantigens, offering a potential avenue for a cure rather than mere symptom management. We discuss this burgeoning field of vaccine development against inflammation and autoimmune diseases, with a focus on common autoimmune disorders, including multiple sclerosis, type 1 diabetes, rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus. Vaccine-based strategies provide a new pathway for the future of autoimmune disease therapeutics, heralding a new era in the battle against inflammation and autoimmunity.

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형식Review Paper
게재일2023년 11월 (BRIC 등록일 2023-12-06)
연구진국외 연구진
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