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Chem. Eng. J., Volume 479, 1 January 2024, 147703 | https://doi.org/10.1016/j.cej.2023.147703 Polymeric amino-single-benzene nano-aggregates (PANA) as a Next-Generation glioblastoma photodynamic therapy

Jaehoon Kim ^a,1, Jin Hee Kim ^b,1, Eun Woo Seo ^a, Youngwoong Kim^a, Jisoo Kang ^a, Chang Woo Koh^c, In Gyoung Ju^d, Hyeyoon Eo ^b, Sungnam Park^c, Myung Sook Oh ^b, Dokyoung Kim ^{a,e,f,g,h,i,j}

^aDepartment of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

^bDepartment of Biomedical and Pharmaceutical Science, Kyung Hee University, Seoul 02447, Republic of Korea

^cDepartment of Chemistry and Research Institute for Natural Science, Korea University, Seoul 02841, Republic of Korea

^dDepartment of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea

^eDepartment of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea

^fMedical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, Core Research Institute (CRI), Kyung Hee University, Seoul 02447, Republic of Korea

^gCenter for Converging Humanities, Kyung Hee University, Seoul 02447, Republic of Korea

^hKHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea

ⁱUC San Diego Materials Research Science and Engineering Center, La Jolla, CA 92093, USA

^jDepartment of Precision Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

¹These authors contributed equally.

Corresponding authors : Myung Sook Oh, Dokyoung Kim

Abstract

Photodynamic therapy (PDT) has been highlighted as a promising strategy for tumor treatment, using in situ reactive oxygen species (ROS) generation which is achieved by irradiating a photosensitizer (PS) with a specific wavelength of light. The efficiency of PDT treatment is enhanced by the high intersystem crossing (ISC) process of PS, which promotes the generation of ROS. Herein, we disclosed a next-generation PS based on polymeric amino-single-benzene nano-aggregates (PANA) that show superior PDT efficacy by improving the ISC process. PANA demonstrates numerous advantageous features for practical applications, such as facile one-pot synthesis, high scalability (>10 g), a bright red emission, high physicochemical stability, high biosafety, and high PDT efficacy. In our study, PANA was applied for the glioblastoma (GBM) treatment using PDT, and it showed exceptional GBM homing properties and high therapeutic efficacy in the mouse animal model without any biological toxicity issues.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2023-12-01)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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