김경민 (이화여자대학교) | 한빛사논문 > 한빛사

한빛사논문

조회455

이화여자대학교

CV File 14 kb

Exp. Mol. Med., Dec 01 2023, | https://doi.org/10.1038/s12276-023-01126-6 IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes

Gyeong Min Kim^1,2, Jihee Kim^1,2, June-Yong Lee³, Min-Chan Park⁴ and Soo Young Lee^1,2,5

¹Department of Life Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.

²The Research Center for Cellular Homeostasis, Ewha Womans University, Seoul 03760, Republic of Korea.

³Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, and Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

⁴Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 06273, Republic of Korea.

⁵Multitasking Macrophage Research Center, Ewha Womans University, Seoul 03760, Republic of Korea.

Corresponding author : Correspondence to Soo Young Lee.

Abstract

Osteoarthritis (OA) is a degenerative joint disease. While it is classically characterized by articular cartilage destruction, OA affects all tissues in the joints and is thus also accompanied by local inflammation, subchondral bone changes, and persistent pain. However, our understanding of the underlying subchondral bone dynamics during OA progression is poor. Here, we demonstrate the contribution of immunoglobulin superfamily 11 (IgSF11) to OA subchondral bone remodeling by using a murine model. In particular, IgSF11 was quickly expressed by differentiating osteoclasts and upregulated in subchondral bone soon after destabilization-of-the-medial-meniscus (DMM)-induced OA. In mice, IgSF11 deficiency not only suppressed subchondral bone changes in OA but also blocked cartilage destruction. The IgSF11-expressing cells in OA subchondral bone were found to be involved in osteoclast maturation and bone resorption and colocalized with receptor-activator of nuclear-factor κ-B (RANK), the key osteoclast differentiation factor. Thus, our study shows that blocking early subchondral bone changes in OA can ameliorate articular cartilage destruction in OA.

논문정보

형식Research article
게재일2023년 12월 (BRIC 등록일 2023-12-04)
연구진국내 연구진
분야 생명과학 > 면역학

댓글 작성 로그인

CV 열람하기

연락처 보기