윤지민 (KAIST)

한빛사논문

조회463

KAIST

CV File 194 kb

Exp. Mol. Med., Dec 01 2023, | https://doi.org/10.1038/s12276-023-01121-x Mitochondrial nucleic acids in innate immunity and beyond

Jimin Yoon^1,8, Sujin Kim^1,8, Mihye Lee^2,3 and Yoosik Kim^1,4,5,6,7

¹Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.

²Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan 31151, Republic of Korea.

³Department of Integrated Biomedical Science, Soonchunhyang University, Cheonan 31151, Republic of Korea.

⁴Graduate School of Engineering Biology, KAIST, Daejeon 34141, Republic of Korea.

⁵KAIST Institute for BioCentury (KIB), KAIST, Daejeon 34141, Republic of Korea.

⁶KAIST Institute for Health Science and Technology (KIHST), KAIST, Daejeon 34141, Republic of Korea.

⁷BioProcess Engineering Research Center and BioInformatics Research Center, KAIST, Daejeon 34141, Republic of Korea.

⁸These authors contributed equally: Jimin Yoon, Sujin Kim.

Corresponding authors : Correspondence to Mihye Lee or Yoosik Kim.

Abstract

Mitochondria participate in a wide range of cellular processes. One essential function of mitochondria is to be a platform for antiviral signaling proteins during the innate immune response to viral infection. Recently, studies have revealed that mitochondrion-derived DNAs and RNAs are recognized as non-self molecules and act as immunogenic ligands. More importantly, the cytosolic release of these mitochondrial nucleic acids (mt-NAs) is closely associated with the pathogenesis of human diseases accompanying aberrant immune activation. The release of mitochondrial DNAs (mtDNAs) via BAX/BAK activation and/or VDAC1 oligomerization activates the innate immune response and inflammasome assembly. In addition, mitochondrial double-stranded RNAs (mt-dsRNAs) are sensed by pattern recognition receptors in the cytosol to induce type I interferon expression and initiate apoptotic programs. Notably, these cytosolic mt-NAs also mediate adipocyte differentiation and contribute to mitogenesis and mitochondrial thermogenesis. In this review, we summarize recent studies of innate immune signaling pathways regulated by mt-NAs, human diseases associated with mt-NAs, and the emerging physiological roles of mt-NAs.

논문정보

형식Review Paper
게재일2023년 12월 (BRIC 등록일 2023-12-06)
연구진국내 연구진
분야 생명과학 > 분자생물학

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