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- 조회505
Exp. Mol. Med., Dec 01 2023, | https://doi.org/10.1038/s12276-023-01117-7
Tumor-suppressive functions of protein lysine methyltransferases
Nur Aziz1,2, Yo Han Hong1,2, Han Gyung Kim1, Ji Hye Kim1 and Jae Youl Cho1
1Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of Korea.
2These authors contributed equally: Nur Aziz, Yo Han Hong.
Corresponding authors : Correspondence to Han Gyung Kim, Ji Hye Kim or Jae Youl Cho.
Abstract
Protein lysine methyltransferases (PKMTs) play crucial roles in histone and nonhistone modifications, and their dysregulation has been linked to the development and progression of cancer. While the majority of studies have focused on the oncogenic functions of PKMTs, extensive evidence has indicated that these enzymes also play roles in tumor suppression by regulating the stability of p53 and β-catenin, promoting α-tubulin-mediated genomic stability, and regulating the transcription of oncogenes and tumor suppressors. Despite their contradictory roles in tumorigenesis, many PKMTs have been identified as potential therapeutic targets for cancer treatment. However, PKMT inhibitors may have unintended negative effects depending on the specific cancer type and target enzyme. Therefore, this review aims to comprehensively summarize the tumor-suppressive effects of PKMTs and to provide new insights into the development of anticancer drugs targeting PKMTs.
논문정보
- Review Paper
- 2023년 12월 (BRIC 등록일 2023-12-01)
- 국내 연구진
- 생명과학 > 면역학
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