강문성 (부산대학교)

한빛사논문

조회360

부산대학교

CV File 1 MB

Nanoscale Horiz., Nov 30 2023, | https://doi.org/10.1039/d3nh00428g MXene and Xene: promising frontier beyond graphene in tissue engineering and regenerative medicine

Moon Sung Kang,^†a, Hee Jeong Jang,^†a, Hyo Jung Jo,^a, Iruthayapandi Selestin Raja^b and Dong-Wook Han^*,a,b

^aDepartment of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan 46241, Republic of Korea

^bBIO-IT Fusion Technology Research Institute, Pusan National University, Busan 46241, Republic of Korea

† These authors contributed equally to the paper.

^*Corresponding author : Dong-Wook Han

Abstract

The emergence of 2D nanomaterials (2D NMs), which was initiated by the isolation of graphene (G) in 2004, revolutionized various biomedical applications, including bioimaging and -sensing, drug delivery, and tissue engineering, owing to their unique physicochemical and biological properties. Building on the success of G, a novel class of monoelemental 2D NMs, known as Xenes, has recently emerged, offering distinct advantages in the fields of tissue engineering and regenerative medicine. In this review, we focus on the comparison of G and Xene materials for use in fabricating tissue engineering scaffolds. After a brief introduction to the basic physicochemical properties of these materials, recent representative studies are classified in terms of the engineered tissue, i.e., bone, cartilage, neural, muscle, and skin tissues. We analyze several methods of improving the clinical potential of Xene-laden scaffolds using state-of-the-art fabrication technologies and innovative biomaterials. Despite the considerable advantages of Xene materials, critical concerns, such as biocompatibility, biodistribution and regulatory challenges, should be considered. This review and collaborative efforts should advance the field of Xene-based tissue engineering and enable innovative, effective solutions for use in future tissue regeneration.

논문정보

형식Review Paper
게재일2023년 11월 (BRIC 등록일 2023-12-04)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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