한빛사논문
- 조회490
Ginam Han a,b,1, Hyun Lee a,b,1, Jeon Min Kang c, Jung-Hoon Park c, Eunsol Lee a,b, Eun Seong Lee a,b, Sinwoo Park a,b, Yuhyun Na a,b, Min-Ho Kang a,b, Nahyun Kim a,b, Seo-Jun Bang a,b, Kun Na a,b, Chang-Bun Yoon d, SeKwon Oh e, Bo Lei f, Joo Dong Park g, Wooram Park g, Hyun-Do Jung a,b
aDepartment of Biomedical-Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon, Gyeonggi 14662, Republic of Korea
bDepartment of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon, Gyeonggi 14662, Republic of Korea
cBiomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea
dDepartment of Advanced Materials Engineering, Tech University of Korea, Siheung, Gyeonggi 15073, Republic of Korea
eResearch Institute of Advanced Manufacturing & Materials Technology, Korea Institute of Industrial Technology, Incheon 21999, Republic of Korea
fFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China
gDepartment of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi 16419, Republic of Korea
1Both authors contributed equally to this work.
Corresponding authors : Wooram Park, Hyun-Do Jung
Abstract
Multimodal cancer treatment that combines anticancer drug delivery with other therapeutic strategies, such as photothermal therapy, has shown enormous potential for biomedical applications. However, traditional nanoscale photothermal conversion agents require complicated synthesis processes and lack biosafety, detectability, and mechanical reinforcement ability in the hyperthermia platform. Here, we engineered near-infrared laser (NIR)-responsive bullets as multifunctional nanodrug platforms via a three-dimensional (3D) printing process as an image-guided versatile chemo-photothermal cancer treatment platform. This customizable platform not only serves as a container for anticancer nanodrugs but also possesses excellent radiopacity and high photothermal conversion efficiency, merging on-demand anticancer nanodrug release and hyperthermia effect. Benefiting from the combined chemo-photothermal therapy, the 3D-printed platform showed enhanced cytotoxicity to cancer cells in vitro. Furthermore, in vivo results confirmed effective on-demand nanodrug release and synergistic inhibition of tumor growth upon NIR laser irradiation. 3D-printed NIR-responsive bullets can synergistically enhance anticancer efficiency while evading potential clinical application risks, offering great potential for multimodal cancer therapies.
논문정보
- Research article
- 2023년 12월 (BRIC 등록일 2023-11-30)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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