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- 조회711
Mol. Psychiatr., Nov 28 2023, | https://doi.org/10.1038/s41380-023-02320-8
Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory
Jaegeon Lee1,2, Seung Ha Kim1,2, Dong Cheol Jang1, Mirae Jang1,2, Myeong Seong Bak1,2, Hyun Geun Shim1,2, Yong-Seok Lee1,2,3 and Sang Jeong Kim1,2,3
1Department of Physiology, Seoul National University College of Medicine, Seoul 03080, Korea.
2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.
3Memory Network Medical Research Center, Neuroscience Research Institute, Wide River Institute of Immunology, Seoul National University College of Medicine, Seoul 03080, Korea
Corresponding author : Correspondence to Sang Jeong Kim.
Abstract
Two forms of plasticity, synaptic and intrinsic, are neural substrates for learning and memory. Abnormalities in homeostatic plasticity cause severe neuropsychiatric diseases, such as schizophrenia and autism. This suggests that the balance between synaptic transmission and intrinsic excitability is important for physiological function in the brain. Despite the established role of synaptic plasticity between parallel fiber (PF) and Purkinje cell (PC) in fear memory, its relationship with intrinsic plasticity is not well understood. Here, patch clamp recording revealed depression of intrinsic excitability in PC following auditory fear conditioning (AFC). Depressed excitability balanced long-term potentiation of PF-PC synapse to serve homeostatic regulation of PF-evoked PC firing. We then optogenetically manipulated PC excitability during the early consolidation period resulting in bidirectional regulation of fear memory. Fear conditioning-induced synaptic plasticity was also regulated following optogenetic manipulation. These results propose intrinsic plasticity in PC as a novel mechanism of fear memory and elucidate that decreased intrinsic excitability in PC counterbalances PF-PC synaptic potentiation to maintain fear memory in a normal range.
논문정보
- Research article
- 2023년 11월 (BRIC 등록일 2023-11-29)
- 국내 연구진
- 의약학 > 신경의학
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