손창규 (대전대학교 한의과대학(대전한방병원)) | 한빛사논문 > 한빛사

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대전대학교 한의과대학(대전한방병원)

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Autoimmun. Rev., Nov 26 2023, S1568-9972(23)00218-5 | https://doi.org/10.1016/j.autrev.2023.103484 Brain-regional characteristics and neuroinflammation in ME/CFS patients from neuroimaging: A systematic review and meta-analysis

Jin-Seok Lee ^a,b, Wakiro Sato ^c, Chang-Gue Son ^a,b

^aResearch Center for CFS/ME, Daejeon Hospital of Daejeon University, Daejeon, Republic of Korea

^bInstitute of Bioscience & Integrative Medicine, Daejeon University, Daejeon, Republic of Korea

^cDepartment of Immunology, National Center of Neurology and Psychiatry, Tokyo, Japan

Corresponding author : Chang-Gue Son

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterized by an elusive etiology and pathophysiology. This study aims to evaluate the pathological role of neuroinflammation in ME/CFS by conducting an exhaustive analysis of 65 observational studies. Four neuroimaging techniques, including magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), electroencephalography (EEG), and positron emission tomography (PET), were employed to comparatively assess brain regional structure, metabolite profiles, electrical activity, and glial activity in 1529 ME/CFS patients (277 males, 1252 females) and 1715 controls (469 males, 1246 females). Clinical characteristics, including sex, age, and fatigue severity, were consistent with established epidemiological patterns. Regional alterations were most frequently identified in the cerebral cortex, with a notable focus on the frontal cortex. However, our meta-analysis data revealed a significant hypoactivity in the insular and thalamic regions, contrary to observed frequencies. These abnormalities, occurring in pivotal network hubs bridging reason and emotion, disrupt connections with the limbic system, contributing to the hallmark symptoms of ME/CFS. Furthermore, we discuss the regions where neuroinflammatory features are frequently observed and address critical neuroimaging limitations, including issues related to inter-rater reliability. This systematic review serves as a valuable guide for defining regions of interest (ROI) in future neuroimaging investigations of ME/CFS.

논문정보

형식Review Paper
게재일2023년 11월 (BRIC 등록일 2023-11-30)
연구진국내(교신)+국외 연구진
분야 의약학 > 한의학

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