정상용 (차의과학대학교, National University of Singapore) | 한빛사논문 > 한빛사

한빛사논문

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정상용Sangyong Jung

차의과학대학교, National University of Singapore

Gut Microbes, Dec 2023, 15 (2) | https://doi.org/10.1080/19490976.2023.2283911 Nuanced contribution of gut microbiome in the early brain development of mice

Xin Yi Yeo ^1,2, Woo Ri Chae^1,3, Hae Ung Lee ⁴, Han-Gyu Bae⁵, Sven Pettersson^4,6,7, Joanes Grandjean ^8,9, Weiping Han ¹, Sangyong Jung ^1,10,11

¹Lab of Metabolic Medicine, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.

²Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

³Department of BioNano Technology, Gachon University, Seongnam, Republic of Korea.

⁴National Neuroscience Institute, Tan Tock Seng Hospital, Singapore Health Services, Singapore, Singapore.

⁵Department of Cellular & Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

⁶Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

⁷Department of Medical Sciences, Sunway University, Kuala Lumpur, Malaysia.

⁸Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.

⁹Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

¹⁰Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

¹¹Department of Medical Science, College of Medicine, CHA University, Seongnam, Republic of Korea.

Correspondence : Weiping Han, Sangyong Jung

Abstract

The complex symbiotic relationship between the mammalian body and gut microbiome plays a critical role in the health outcomes of offspring later in life. The gut microbiome modulates virtually all physiological functions through direct or indirect interactions to maintain physiological homeostasis. Previous studies indicate a link between maternal/early-life gut microbiome, brain development, and behavioral outcomes relating to social cognition. Here we present direct evidence of the role of the gut microbiome in brain development. Through magnetic resonance imaging (MRI), we investigated the impact of the gut microbiome on brain organization and structure using germ-free (GF) mice and conventionalized mice, with the gut microbiome reintroduced after weaning. We found broad changes in brain volume in GF mice that persist despite the reintroduction of gut microbes at weaning. These data suggest a direct link between the maternal gut or early-postnatal microbe and their impact on brain developmental programming.

논문정보

형식Brief Report
게재일2023년 12월 (BRIC 등록일 2023-12-04)
연구진국내(교신)+국외 연구진
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