한빛사논문
- 조회575
한국과학기술연구원(KIST)
Jihoon Ko1†,*, Jiyoung Song2†, Nakwon Choi2,3,4, and Hong Nam Kim2,3,5,6*
1Department of BioNano Technology, GachonUniversity, Seongnam-si, Gyeonggi-do 13120, Republic of Korea
2Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of KoreaN. Choi, H. N. Kim
3Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea
4KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul02841, Korea
5School of Mechanical Engineering, Yonsei University, Seoul 03722, Republic of Korea
6Yonsei-KIST Convergence Research Institute, Yonsei University, Seoul 03722, Republic of Korea
†These authors contributed equally to this work.
*Corresponding authors : Jihoon Ko, Hong Nam Kim
Abstract
Patient-derived microphysiological systems (P-MPSs) have emerged as powerful tools in precision medicine that provide valuable insight into individual patient characteristics. This review discusses the development of P-MPS as an integration of patient-derived samples, including patient-derived cells, organoids, and induced pluripotent stem cells, into well-defined microphysiological systems. Emphasizing the necessity of P-MPS development, we highlighted its significance as a nonclinical assessment approach that bridges the gap between traditional in vitro models and clinical outcomes. Additionally, we provide guidance for engineering approaches to develop microfluidic devices and high-content analysis for P-MPSs, enabling high biological relevance and high-throughput experimentation. The practical implications of the P-MPS were further examined by exploring the clinically relevant outcomes obtained from various types of patient-derived samples. The construction and analysis of these diverse samples within the P-MPS have resulted in physiologically relevant data, paving the way for the development of personalized treatment strategies. This study describes the significance of the P-MPS in precision medicine as well as its unique capacity to offer valuable insights into individual patient characteristics.
논문정보
- Review Paper
- 2023년 11월 (BRIC 등록일 2023-11-28)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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