한빛사논문
- 조회443
Ikjae Lee 1, Hiroshi Mitsumoto 1, Seonjoo Lee 2,3, Edward Kasarskis 4, Michael Rosenbaum 5, Pam Factor-Litvak 6, Jeri W Nieves 6
1Department of Neurology Columbia University Irving Medical Center, New York, NY.
2Department of Biostatistics and Psychiatry, Columbia University, New York, NY.
3Mental Health Data Science, New York State Psychiatric Institute, New York, NY.
4Department of Neurology, University of Kentucky, Lexington, KY.
5Department of Pediatrics and Medicine, Columbia University Irving Medical Center, New York, NY.
6Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY.
CORRESPONDING AUTHOR : Ikjae Lee MD MSc
Abstract
Objective: High-caloric diets may slow the progression of amyotrophic lateral sclerosis; however, key macronutrients have not been identified. We examined whether dietary macronutrients are associated with the rate of progression and length of survival among the prospective cohort study participants.
Methods: Participants with a confirmed diagnosis of sporadic amyotrophic lateral sclerosis enrolled in the Multicenter Cohort Study of Oxidative Stress were included (n=304). We evaluated baseline macronutrient intake assessed by food frequency questionnaire in relation to change in revised amyotrophic lateral sclerosis functional rating scale total-score, and tracheostomy-free survival using linear regression and Cox proportional hazard models. Baseline age, sex, disease duration, diagnostic certainty, body mass index, bulbar onset, revised amyotrophic lateral sclerosis functional rating scale total-score, and forced vital capacity were included as covariates.
Results: Baseline higher glycemic index and load were associated with less decline of revised amyotrophic lateral sclerosis functional rating scale total-score at 3-month follow-up (β= -0.13, 95% Confidence Interval [-0.2, -0.01], p=0.03) and (β= -0.01, [-0.03, -0.0007], p=0.04) respectively. Glycemic index second-quartile, third-quartile, and fourth-quartile groups were associated with less decline at 3-month by 1.9 ([-3.3, -0.5], p=0.008), 2.0 ([-3.3, -0.6], p=0.006), and 1.6 ([-3.0, -0.2], p=0.03) points compared to the first-quartile group; glycemic load fourth-quartile group had 1.4 points less decline compared to the first-quartile group ([-2.8, 0.1], p=0.07). Higher glycemic index was associated with a trend toward longer tracheostomy-free survival (Hazard ratio 0.97, [0.93, 1.00], p=0.07).
Interpretation: Higher dietary glycemic index and load are associated with slower disease progression in amyotrophic lateral sclerosis.
논문정보
- Research article
- 2023년 11월 (BRIC 등록일 2023-11-28)
- 국외 연구진
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