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신희권Heegwon Shin
Columbia University Irving Medical Center
Immunity, Nov 14 2023, 56 (11) S1074-7613(23)00455-7 | https://doi.org/10.1016/j.immuni.2023.10.015
SMPDL3A links cholesterol metabolism to the cGAS-STING pathway
Heegwon Shin 1, Hachung Chung 1
1Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA
Corresponding author : Hachung Chung
Abstract
Liver X receptor (LXR), well known for its role in cholesterol metabolism, also has anti-inflammatory properties. In this issue of Immunity, Hou et al. demonstrate that LXR signaling induces SMPDL3A, a cGAMP-degrading enzyme that restricts cGAS-cGAMP-STING innate immune signaling, providing a mechanistic link between lipid metabolism and inflammation.
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- 2023년 11월 (BRIC 등록일 2023-12-05)
- 국외 연구진
- 생명과학 > 면역학
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